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Anti-fatigue compound preparation and preparation method thereof

A compound preparation and anti-fatigue technology, which is applied in the fields of anti-drugs, pill delivery, and pharmaceutical formulations, can solve problems such as obvious anti-fatigue effect, undetermined anti-fatigue functional factors, and unconfirmed anti-fatigue effect, so as to improve drug active effect

Inactive Publication Date: 2015-01-14
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second category is that the anti-fatigue effect is obvious but the structure of its functional factors or functional factors has not yet been determined, such as ginseng, pollen, Acanthopanax, Rhodiola, Polygonatum, Flammulina velutipes, Salvia, Codonopsis, Eucommia, wolfberry, tortoise shell gum, spirulina , starfish, oysters, scallops, etc.
These are all Chinese traditional tonic herbal medicines and their extracts, which are characterized by the anti-fatigue effect has been confirmed by experiments, but their anti-fatigue functional factors have not yet been determined
The third is that the anti-fatigue food formula is often added but its own anti-fatigue effect has not been confirmed by experiments, such as sea dragon, sea cucumber, gecko and other tonic crude drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The compound preparation of this example is a granule, including the following components: Astragalus 620g, Salvia miltiorrhiza 380g, Epimedium 260g, and Huangpiguo 340g.

[0042] The preparation method of this compound preparation comprises the following steps:

[0043] S1. Wash the raw materials, pass the inspection, and pulverize;

[0044] S2. Add Danshen root to 6 times the weight of absolute ethanol for reflux extraction, reflux for 1 hour each time, reflux extraction for 3 times, filter, combine the filtrate, recover ethanol by vacuum distillation, concentrate into a clear paste with a relative density of 1.25-1.3, and set aside;

[0045] S3. Add the solid residue of Salvia miltiorrhiza to Radix Astragali, add water to decoct 3 times, the amount of water added is 6 times the weight of the medicinal material, decoct for 1.5 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.25-1.3, spare...

Embodiment 2

[0051] The compound preparation of this embodiment is a capsule, including the following components: 480 g of astragalus, 360 g of salvia miltiorrhiza, 320 g of epimedium, and 180 g of huangpi fruit.

[0052] The preparation method of this compound preparation comprises the following steps:

[0053] S1. Wash the raw materials, pass the inspection, and pulverize;

[0054] S2. Add Danshen root to 6 times the weight of absolute ethanol for reflux extraction, reflux for 1 hour each time, reflux extraction for 3 times, filter, combine the filtrate, recover ethanol by vacuum distillation, concentrate into a clear paste with a relative density of 1.25-1.3, and set aside;

[0055] S3. Add the solid residue of Salvia miltiorrhiza to Radix Astragali, add water to decoct 3 times, the amount of water added is 6 times the weight of the medicinal material, decoct for 1.5 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative densi...

Embodiment 3

[0061] The compound preparation of this embodiment is a tablet, including the following components: 550 g of Radix Astragali, 430 g of Salvia Miltiorrhiza, 330 g of Epimedium, and 420 g of Huangpi Guo.

[0062] The preparation method of this compound preparation comprises the following steps:

[0063] S1. Wash the raw materials, pass the inspection, and pulverize;

[0064] S2. Add Danshen root to 6 times the weight of absolute ethanol for reflux extraction, reflux for 1 hour each time, reflux extraction for 3 times, filter, combine the filtrate, recover ethanol by vacuum distillation, concentrate into a clear paste with a relative density of 1.25-1.3, and set aside;

[0065] S3. Add the solid residue of Salvia miltiorrhiza to Radix Astragali, add water to decoct 3 times, the amount of water added is 6 times the weight of the medicinal material, decoct for 1.5 hours each time, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative den...

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Abstract

The invention discloses an anti-fatigue compound preparation and a preparation method thereof, wherein the preparation comprises the following components in percentages by weight: 10-65% of salvia miltiorrhiza, 15-35% of astragalus, 15-35% of herba epimedii and 5-20% of Chinese wampee fruit. In the invention, the salvia miltiorrhiza, astragalus, herba epimedii and Chinese wampee fruit are adopted, which contain phenolic acids, flavonoids, pectin, polysaccharides and saponin compounds, have the functions of increasing coronary blood flow, reducing blood lipid, inhibiting thrombosis, improving microcirculation, eliminating free radicals, preventing oxidization and the like, and can be used for preventing body fatigue and movement injuries, enhancing the body immunity and protecting the organs and tissues from being damaged. A variety of nutrients in the present invention activate the immune systems at different levels and generate a comprehensive anti-fatigue effect, the traditional Chinese medicine with an immunity enhancement function is prepared into a novel compound preparation by means of modern extraction separation and preparation formation process, to improve the activity of the drug.

Description

technical field [0001] The invention relates to a compound preparation, which belongs to the technical field of medicine or health product composition, in particular to an anti-fatigue compound preparation and a preparation method thereof. Background technique [0002] Fatigue refers to the weakening of body function caused by excessive exercise, lack of sleep, disease and other reasons. Subjectively, there is discomfort such as fatigue and weakness, which leads to a decrease in work efficiency. With the acceleration of the pace of life and the increase of work pressure, fatigue has increasingly become an important factor affecting people's quality of life. According to the WHO survey, more than 35% of people in the world are in a state of fatigue, and the fatigue state of middle-aged male population reaches 60%. The appearance of fatigue can lead to reduced athletic ability, reduced work efficiency, increased errors and accidents, and decreased combat effectiveness. If f...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61P39/00
CPCA61K36/296A61K9/1652A61K9/2059A61K9/4858A61K36/481A61K36/537A61K36/75A61K2236/15A61K2236/33A61K2236/331A61K2236/333A61K2236/51
Inventor 吕应年
Owner GUANGDONG MEDICAL UNIV
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