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Medicament reutilization method based on omics data

A technology of reuse and drugs, applied in special data processing applications, electrical digital data processing, instruments, etc., can solve the problems that it is difficult to comprehensively mine valuable drugs for treating diabetes

Inactive Publication Date: 2014-12-17
奚正蕊 +1
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Problems solved by technology

Existing drug repurposing methods are only based on in vitro, animal experiment data or gene association data of clinical samples, and it is difficult to comprehensively mine valuable drugs for treating diabetes

Method used

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  • Medicament reutilization method based on omics data
  • Medicament reutilization method based on omics data

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Embodiment 1

[0012] Drug repurposing method based on omics data to mine drugs for treating diabetes in humans

[0013] The research and development of antidiabetic drugs faces problems such as long research and development cycle, high research and development costs, and drug safety. The drug repositioning method rediscovers new uses of old drugs and drugs that have failed in research and development, and has the advantages of short development time, low cost, and less safety risks. The present invention uses the genome wide association study (GWAS) of clinical samples, proteomics and metabolomics data to construct 992 protein targets with potential therapeutic effects on human diabetes. By comparing with the Therapeutic target database (TTD) information, 108 proteins have corresponding drug development information (at least one drug has an effect on the protein target), of which 35 proteins have corresponding drugs that are in clinical research Or already on the market stage, called drug ...

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Abstract

The invention discloses a novel method for medicament reutilization, and particularly relates to a method for integrating data analysis results of human diabetes-associated whole-genome association analysis, proteomics and metabonomics, screening human diabetes-associated risk proteins, exploring information of marking medicaments or clinical experiment medicaments working on the human diabetes-associated risk proteins by combining a medicament development database, and integrating pathogenesis information of human diabetes through a public database. According to the method, 58 marking medicaments or clinical experiment medicaments aiming at other diseases are excavated, and a novel purpose for treating the human diabetes is achieved.

Description

technical field [0001] The invention belongs to the application of a new method of drug reuse, in particular to the treatment of human diabetes by mining some marketed drugs and clinical experimental drugs through clinical omics data. Background technique [0002] Drug repurposing methods, also known as drug repurposing, or repurposing old drugs, have been widely used in discovering new uses of marketed drugs and drugs in clinical trials (Ashburn et al., Nat Rev Drug Discov 2004). Most of the previous successful cases of drug repurposing were discovered by chance (Sardan et al., Brief Bioinform 2011). In recent years, many advances have been made in systematic drug repurposing methods using data from in vitro samples, animal models, and clinical samples, such as comparing the effects of different drugs on the gene expression profile of cells (connectivity map, CMap) (Lamb et al., Science 2006 ), network analysis (Chindelevitch et al., Bioinformatics 2012), computational bio...

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Application Information

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IPC IPC(8): G06F19/10
Inventor 张明奚正蕊
Owner 奚正蕊
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