Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chitosan gel haemostatic material and preparation method thereof

A technology of chitosan gel and hemostatic material is applied in the field of biomaterial and gel preparation, which can solve the problems of physiological toxicity and unsatisfactory hemostatic effect, achieve short hemostasis time, good self-healing ability, and avoid postoperative infection. Effect

Active Publication Date: 2014-12-10
BEIJING UNIV OF CHEM TECH
View PDF7 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The general principle of traditional hemostatic materials is to enrich platelets by charge or to bind tissue to stop bleeding. Due to some defects in this kind of materials, the hemostatic effect is not ideal, and there are still some characteristics of physiological toxicity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan gel haemostatic material and preparation method thereof
  • Chitosan gel haemostatic material and preparation method thereof
  • Chitosan gel haemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PEG and a mixed solution of 300 U / mL thrombin, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation glue.

Embodiment 2

[0022] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PEG and a mixed solution of 300 U / mL thrombin, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation Gel, freeze-dried to obtain xerogel.

Embodiment 3

[0024] Take 3 chitosan solutions with a volume concentration of 3.0 mg / mL, add 1 volume concentration of 10.0 mg / mL of DF-PVA and 300 U / mL thrombin mixed solution, mix and react at room temperature for 2 minutes, and obtain chitosan hydrocoagulation glue.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of deacetylationaaaaaaaaaa
Login to View More

Abstract

The invention relates to a chitosan gel haemostatic material and a preparation method thereof. The chitosan gel haemostatic material is compounded of chitosan, a cross-linking agent and thrombin. The chitosan gel haemostatic material disclosed by the invention is good in biocompatibility and biodegradability; hydrogel is excellent in mucous membrane viscosity and self-adaptability, and has functions of quickly stopping blooding in body, promoting wound healing and releasing thrombin slowly so as to prevent secondary blooding caused by postoperative motion; meanwhile, the haemostatic material has characteristics of bacteria resistance and bacteriostasis and is capable of effectively preventing wound infection.

Description

technical field [0001] The invention belongs to the technical field of biological materials and gel preparation, and relates to a chitosan gel hemostatic material and a preparation method thereof. Background technique [0002] In recent years, many studies have shown that in the first aid treatment of sudden accidents, trauma hemostasis during surgery, especially in the rescue of wounded people in war, it is very important for patients to effectively and quickly stop bleeding locally. Rapid hemostasis materials can effectively reduce casualties. According to the mechanism of hemostasis, people currently use four methods to stop bleeding: one is to promote vasoconstriction, reduce capillary permeability, reduce blood flow, and promote the coagulation process at damaged blood vessels. The second is to increase the number of platelets, enhance their aggregation and adhesion, and promote the release of coagulation active substances from platelets to achieve the purpose of hemos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44C08J3/075C08L5/08
Inventor 王兴李永三
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com