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Sugar-free lysine zinc gluconate granules and quality detection method thereof

A zinc lysine, sugar-free technology, applied in the field of medicine, can solve the problems that it is not suitable for the determination of lysine hydrochloride content, and cannot effectively use quality control methods.

Active Publication Date: 2014-12-03
厦门康艺迈医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] Unfortunately, however, these existing methods cannot be effectively used as a quality control method for the composition of the present invention, and are particularly not suitable for the content determination and related substance determination of lysine hydrochloride in the composition of the present invention.

Method used

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  • Sugar-free lysine zinc gluconate granules and quality detection method thereof
  • Sugar-free lysine zinc gluconate granules and quality detection method thereof
  • Sugar-free lysine zinc gluconate granules and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0214] Embodiment 1: preparation zinc lysine gluconate granule composition

[0215] formula:

[0216]

[0217] Preparation method:

[0218] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 90 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving it to obtain a clear solution;

[0219] (2) Adjust an appropriate amount of starch (accounting for 50% of the prescription amount) into a paste with 2 times the weight of water, then mix it evenly with the solution obtained in step (1), stir and heat up to 70° C. to obtain solution I, spare;

[0220] (3) Make the remaining amount of starch into a paste with 8 times the weight of water, stir and heat up to 70°C at the same time to obtain solution II, which is set aside;

[0221] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 70°C, spray into solution I, and then spr...

Embodiment 2

[0224] Embodiment 2: preparation zinc lysine gluconate granule composition

[0225] formula:

[0226]

[0227] Preparation method:

[0228] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 80 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving them to obtain a clear solution;

[0229] (2) Adjust an appropriate amount of starch (accounting for 60% of the prescription amount) into a paste with 2 times the weight of water, then mix evenly with the solution obtained in step (1), stir and heat up to 65° C. to obtain solution I, spare;

[0230] (3) Make the remaining amount of starch into a paste with 6 times the weight of water, stir and heat up to 75°C at the same time to obtain solution II, which is set aside;

[0231] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 65°C, spray into solution I, and then sp...

Embodiment 3

[0234] Embodiment 3: preparation zinc lysine gluconate granule composition

[0235] formula:

[0236]

[0237] Preparation method:

[0238] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 110 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving it to obtain a clear solution;

[0239] (2) Adjust an appropriate amount of starch (accounting for 40% of the prescription amount) into a paste with 2 times the weight of water, then mix it evenly with the solution obtained in step (1), stir and heat up to 75° C. to obtain solution I, spare;

[0240] (3) Make the remaining amount of starch into a paste with 10 times the weight of water, stir and heat up to 75°C at the same time to obtain solution II, which is set aside;

[0241] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 75°C, spray into solution I, and then...

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Abstract

The invention relates to sugar-free lysine zinc gluconate granules and a quality detection method thereof, specifically belongs to the technical field of medicine, relates to a composition for supplementing lysine and zinc, especially zinc gluconate, in particular relates to granules for supplementing lysine and zinc, especially zinc gluconate, and more in particular relates to sugar-free lysine zinc gluconate granules for supplementing lysine and zinc, especially zinc gluconate. The invention also relates to a method for performing quality detection on the sugar-free lysine zinc gluconate granules. The lysine zinc gluconate granules are a mineral substance type OTC medicine. The sugar-free lysine zinc gluconate granules are clinically used for preventing and treating growth retardation, malnutrition, anorexia and the like of children and adolescents due to lack of lysine and zinc. The lysine contained in the lysine zinc gluconate granules is one of essential amino acids for maintaining the nitrogen balance of a human body and has the effect of promoting the growth of the human body; zinc is an important component for a plurality of enzymes in vivo, and has the effects of promoting growth and development and improving gustation.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a composition for supplementing lysine and zinc, especially zinc gluconate, in particular to a granule for supplementing lysine and zinc, especially zinc gluconate, more particularly The invention relates to a sugar-free granule for supplementing lysine and zinc, especially zinc gluconate. The invention also relates to a method for quality detection of the sugar-free zinc lysine glucose granules. Background technique [0002] Lysine, also known as L-lysine hydrochloride, is an essential amino acid. The English name of lysine is lysine, the abbreviation is Lys, the single-letter abbreviation of amino acid is K, and its chemical formula is H 2 NCH 2 CH 2 CH 2 CH 2 CH(NH 2 )COOH, molecular formula: C 6 h 14 N 2 o 2 , molecular weight 146.19, CAS No. 56-87-1, chemical structural formula: [0003] [0004] Symptoms of lysine deficiency include fatigue, weakness, nausea, vomi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/315A61K9/16G01N30/02G01N30/06A61P3/02
Inventor 郑敬操
Owner 厦门康艺迈医药科技有限公司
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