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Improved suture

A suture thread and thread anchor technology, applied in medical science, surgery, prosthesis, etc., can solve problems such as unfavorable neovascularization

Active Publication Date: 2014-11-26
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pore ​​sizes less than about 200 microns are known to be watertight and detrimental to neovascularization

Method used

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Examples

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example 1

[0067] Finite Element Analysis of the Suture / Tissue Interface for Sutured Abdominal Wall Closure

[0068] Experiments were performed during the development of embodiments of the present disclosure to perform finite element analysis of the suture / tissue interface for sutured abdominal wall closure. As a first step in the design of this series of inquiries, create a theoretical basis for intuitive concepts and clinical observations (see figure 1 , figure 2 ). A finite element analysis of the suture / tissue interface was performed ( image 3 ). Experiments have shown that increasing suture size (i.e., diameter) reduces the force at the suture / tissue interface as hypothesized ( Figure 4 ). also demonstrated that the shape of the suture affects the local force exerted by the suture on the tissue ( Figure 5 ).

example 2

[0070] An "equivalence" is created between conventional sutures and the macroporous sutures of the present disclosure.

[0071] O-shaped polypropylene suture is commonly used in hernia repair because of its handling and high strength characteristics. Experiments were performed to determine a relatively equivalent cross-sectional profiled suture to such sutures. A 2D suture is compared to this commonly used standard suture in terms of yield load, maximum load, and Young's modulus. Mechanical tests were performed using an Instron 5964. Experiments have shown the relative equivalence between O-type polypropylene and 2D ribbon sutures with a width of 5 mm ( Figure 6 and Figure 7 ). A 5-0 polypropylene suture (used in experimental murine hernia repair) was equivalent to a 2 mm wide sample of the macroporous suture of the present disclosure.

example 3

[0073] Create and validate deep suture pullthrough models using biological tissue and tension measurements

[0074] The alba linea was purchased from a local abattoir to provide a practical trial of very deep suture pullthroughs. Standard sutures and macroporous sutures of the present disclosure were passed through porcine tissue equally. To reduce biological variability, adjacent sheets of fascia were randomized to either standard sutures or two-dimensional sutures, with suture perforations of width mimicking the clinical situation (1 cm from the edge). Tension measurements were performed using an Instron 5964, testing slow and fast suture pulls to simulate baseline suture tension and occasional high tension (eg, coughing, going up stairs, etc.). An appropriate number of trials were performed on both standard sutures and the macroporous sutures of the present disclosure, taking into account biological variability and readily available biomaterials.

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Abstract

A medical device includes a surgical needle attached to a hollow tubular suture. The suture is constructed of macroporous hollow tubular wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.

Description

[0001] Cross References to Related Applications [0002] The benefit of priority of U.S. Provisional Patent Application No. 61 / 602,183, filed February 23, 2012, is hereby claimed and incorporated herein by reference in its entirety. technical field [0003] The present disclosure provides sutures having increased surface area and / or tissue-integrating properties, and methods of use and manufacture thereof. In particular, provided herein are sutures having various cross-sectional profiles and other structural properties that enhance closure, prevent suture pull through, and / or resist infection, and methods of use thereof. Background technique [0004] One of the cornerstones of surgery is the use of sutures to draw tissue back together, ie, to hold tissue in the desired shape until it can heal. In principle, suturing is the introduction of high tensile strength external structures (looped sutures) into separate pieces of tissue in order to hold the pieces close together unti...

Claims

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Application Information

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IPC IPC(8): A61B17/06
CPCA61B2017/00526A61B2017/0608A61B2017/0464A61L17/00A61B2017/0417A61B2017/06185A61B17/06A61B2017/0412A61B17/06166A61B2017/061A61B2017/0461Y10T29/49826A61F2/0063A61L17/10
Inventor 格雷戈里·德美琳安纳德吾·格瑞加勒
Owner NORTHWEST UNIV
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