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Preparation method for nine-composition hemorrhoid tablet and application thereof to medicines inhibiting cell proliferation of prostate cancer cell RM-1

A nine-flavor hemorrhoids and extraction technology is applied in the preparation of nine-flavor hemorrhoids tablets, the application field of drugs for inhibiting the proliferation of mouse prostate cancer cells RM-1 cells, and can solve the problems of rough process, affecting clinical application, and many impurities.

Inactive Publication Date: 2014-11-26
JINAN ASIA PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Jiuwei Zhichuang Capsules. However, the method of directly powdering and decocting in water is rough and backward in technology and has many impurities, which leads to excessive dosage for patients and is inconvenient. Taking it seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 400g of Sanyue bubble, 150g of Polygonum cuspidatum, 200g of Burnet, 100g of Liuji, 100g of fig leaf, 50g of chrysanthemum, 20g of chicken white, 150g of Coptis chinensis, and 50g of rhubarb, and add Sanyuebao, Polygonum cuspidatum and Liujisheng to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 5L of 60% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. Each time for 8 minutes, the extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 60% ethanol, collected ...

Embodiment 2

[0033] Take 400g of Sanyue bubble, 150g of Polygonum cuspidatum, 200g of Burnet, 100g of Liuji, 100g of fig leaf, 50g of chrysanthemum, 20g of chicken white, 150g of Coptis chinensis, and 50g of rhubarb, and add Sanyuebao, Polygonum cuspidatum and Liujisheng to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 60% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. Combine extracts for 5 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 60% ethanol, collect 5 times column volume ...

Embodiment 3

[0036] Take 400g of Sanyue bubble, 150g of Polygonum cuspidatum, 200g of Burnet, 100g of Liuji, 100g of fig leaf, 50g of chrysanthemum, 20g of chicken white, 150g of Coptis chinensis, and 50g of rhubarb, and add Sanyuebao, Polygonum cuspidatum and Liujisheng to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 6% by volume of the total extraction solvent, the extraction pressure is 15MPa, the temperature is 30°C, and CO2 The flow rate was 1ml / g crude drug min, the extraction time was 220min, and the supercritical extract was obtained for use; the rest of the traditional Chinese medicine was taken, pulverized, added with 5L of 60% ethanol, put into a microwave extraction device for microwave extraction, the extraction power was 800W, and the extraction was performed twice, For 10 minutes each time, the extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 60% ethanol, collected 5 tim...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and concretely relates to a preparation method for a nine-composition hemorrhoid tablet and application. According to the preparation method for the nine-composition hemorrhoid tablet, 400 g of rubus hirsutus, 150 g of rhizoma polygoni cuspidati, 200 g of radix sanguisorbae, 100 g of herba visci, 100 g of ficus carica leaf, 50 g of flos chrysanthemi, 20 g of egg white, 150 g of rhizoma coptidis and 50 g of radix et rhizoma rhei are employed as bulk drugs, and supercritical extraction and microwave extraction are employed, so that the nine-composition hemorrhoid tablet is substantially improved in emodin content. The invention also provides application of the nine-composition hemorrhoid tablet to prepare medicines inhibiting cell proliferation of mouse prostate cancer cell RM-1.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Jiuwei Zhichuang Tablet and its application in medicines for inhibiting proliferation of mouse prostate cancer cell RM-1 cells. Background technique [0002] The standard number of Jiuwei Zhichuang Capsules is WS-10189 (ZD-0189)-2002, which is recorded in the Surgical Gynecology Subvolume of the National Compilation of Chinese Patent Medicine Standards. Made from 400g Sanyue bubble, 150g Polygonum cuspidatum, 200g Burnet, 100g Liujisheng, 100g fig leaf, 50g chrysanthemum, 20g Chicken White, 150g Coptis chinensis, and 50g rhubarb. Hemostatic effect. . Used for internal hemorrhoid bleeding and external hemorrhoid swelling and pain caused by damp heat accumulation. [0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Jiuwei Zhichuang Caps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/739A61K9/20A61P35/00A61K35/54
Inventor 彭立增孙建林朱富强
Owner JINAN ASIA PHARMA TECH
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