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A kind of preparation method of SERS substrate monolayer film and this SERS substrate monolayer film

A single-layer film and substrate technology, applied in coatings, metal material coating technology, nanotechnology for materials and surface science, etc., can solve the problem of inability to obtain uniform metal nanoparticles on the enhanced substrate, small SERS substrate, Problems such as excellent sensitivity have not been achieved, and the effects of Raman peak strength, high sensitivity, and good recognition have been achieved

Active Publication Date: 2017-02-08
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing reinforced substrates cannot obtain metal nanoparticles with a uniform surface. The method of preparing the metal nanoparticle SERS substrate is mainly to drop the gold nanorod solution on the substrate. After the solvent is completely evaporated, the remaining gold nanorods are on the substrate metal nanorod substrate
However, the scale of the SERS substrate obtained by this method is small (less than tens of microns), the structure is scattered on the substrate discontinuously, cannot be positioned, and the overall state of disorder appears, and excellent sensitivity has not been achieved.

Method used

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  • A kind of preparation method of SERS substrate monolayer film and this SERS substrate monolayer film
  • A kind of preparation method of SERS substrate monolayer film and this SERS substrate monolayer film
  • A kind of preparation method of SERS substrate monolayer film and this SERS substrate monolayer film

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Embodiment 1

[0032] Example 1: Preparation method of gold nanorod tiled self-assembled SERS substrate monolayer film

[0033] The aqueous solution of gold nanorods with an aspect ratio of 3.8 was prepared by seed growth method. The prepared gold nanorod aqueous solution was centrifuged and concentrated, and then dispersed at a concentration of about 1×10 -6 moL -1In the CTAB aqueous solution, the concentration ratio of gold nanorods and CTAB in the obtained gold nanorod CTAB aqueous solution is 1:1000, and it is left to stand for subsequent use. Prepare the ligand replacement solution, that is, the ethanol solution of mercaptoalkane, wherein the volume ratio of mercaptoalkane to ethanol is about 1:9. Take the gold nanorod CTAB aqueous solution in the sample bottle, drop the mercaptoalkane solution and stir at a constant speed at 600r / min for 1 minute, make it fully contact with the gold nanorod for effective ligand replacement, the mercaptoalkane ethanol solution and The volume ratio of...

Embodiment 2

[0035] An aqueous solution of gold nanorods with an aspect ratio of 4.2 was prepared using the seed growth method. The prepared gold nanorod aqueous solution was centrifuged and concentrated, and then dispersed at a concentration of about 15×10 -6 moL -1 In the CTAB aqueous solution, the concentration ratio of gold nanorods and CTAB in the obtained gold nanorod CTAB aqueous solution is 3:1000, and it is left to stand for subsequent use. Prepare the ligand replacement solution, that is, the ethanol solution of mercaptoalkane, wherein the volume ratio of mercaptoalkane to ethanol is about 1:4. Take the gold nanorod CTAB aqueous solution in the sample bottle, drop the mercaptoalkane solution and stir at a constant speed at 800r / min for 6 minutes, make it fully contact with the gold nanorod to carry out effective ligand replacement, the mercaptoalkane ethanol solution and The volume ratio of the gold nanorod CTAB aqueous solution was 1:10 to obtain a ligand replacement mixed sol...

Embodiment 3

[0037] Aqueous solutions of gold nanorods with an aspect ratio of 4.0 were prepared using the seed growth method. The prepared gold nanorod aqueous solution was centrifuged and concentrated, and then dispersed at a concentration of about 8×10 -6 moL -1 In the CTAB aqueous solution, the concentration ratio of gold nanorods and CTAB in the obtained gold nanorod CTAB aqueous solution is 2:1000, and it is left to stand for subsequent use. Prepare the ligand replacement solution, that is, the ethanol solution of mercaptoalkane, wherein the volume ratio of mercaptoalkane to ethanol is about 2:7. Take the gold nanorod CTAB aqueous solution in the sample bottle, add dropwise the mercaptoalkane solution and stir at a constant speed at 700r / min for 4 minutes, make it fully contact with the gold nanorod to carry out effective ligand replacement, the mercaptoalkane ethanol solution and The volume ratio of the gold nanorod CTAB aqueous solution is 1:9 to obtain a ligand replacement mixed...

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Abstract

The invention discloses a method for manufacturing an SERS substrate monolayer film. The method comprises the following steps that (1) gold nanorod aqueous solutions with the length-diameter ratio of 3.8 to 4.2 are prepared; (2) the gold nanorod aqueous solutions are centrifugalized, and then are redissolved and dispersed in CTAB aqueous solutions, and the concentration ratio of gold nanorods to CTAB in the obtained gold nanorod CTAB aqueous solutions is 1 to 3:100; (3) sulfydryl alkane ethanol solutions are prepared, the sulfydryl alkane ethanol solutions are dropwise added into the gold nanorod CTAB aqueous solutions prepared in the step (2), the volume ratio of the sulfydryl alkane ethanol solutions to the gold nanorod CTAB aqueous solutions is 1:9 to 10, the sulfydryl alkane ethanol solutions and the gold nanorod CTAB aqueous solutions are sufficiently stirred, and ligand substitution mixed solutions are obtained; (4) organic solvents are added into the ligand substitution mixed solutions, the volume ratio of the organic solvents to the ligand substitution mixed solutions is 1.1 to 1.5:1, standing is carried out on a sample, and the SERS substrate monolayer film is obtained from a water phase upper surface. The invention further discloses the SERS substrate monolayer film manufactured by the method, and the SERS substrate monolayer film is high in stability, good in enhancing effect, strong in reproducibility and capable of being used for detecting biological probe molecules.

Description

technical field [0001] The present invention relates to a method for preparing a SERS substrate monolayer film and the SERS substrate monolayer film, in particular to a method for preparing a SERS substrate monolayer film and the SERS substrate monolayer film through self-assembly of gold nanorods at the water vapor interface layer film. Background technique [0002] Raman spectroscopy is a non-contact and non-destructive analytical technique based on the interaction of light and chemical bonds within materials. Raman spectroscopy can provide detailed information on a sample's chemical structure, phase and morphology, crystallization, and molecular interactions. But in general, its signal strength is very weak, which limits its application range. How to increase its spectral intensity is a key issue in the study of Raman spectroscopy. Surface-enhanced Raman scattering (SERS) technology overcomes the disadvantage of weak signal inherent in traditional Raman spectroscopy, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C26/00G01N21/65B82Y30/00B82Y40/00
Inventor 葛广路王瑞敏魏文博
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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