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Stable lisinopril tablet and preparation method thereof

A stable and prescription technology, applied in the field of medicine, can solve problems such as difficult to control moisture, loose tablets and tablets are susceptible to moisture and water absorption

Inactive Publication Date: 2014-11-19
SHANGHAI SINE WANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional preparation of lisinopril is a wet granulation process, and the obtained granules are dried in an oven. Due to the high water content of lisinopril raw materials, it is difficult to control the moisture after drying in an oven, and the tablets are easily affected by moisture and water absorption after tableting. , prone to loose film problems

Method used

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  • Stable lisinopril tablet and preparation method thereof
  • Stable lisinopril tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Get lisinopril 100g, calcium hydrogen phosphate 400g, microcrystalline cellulose 450g, starch 250g, hydroxypropyl cellulose 100g, calcium sulfate 450g, carboxymethyl starch sodium 30g and hypromellose 4g, cross 30 mesh sieves;

[0048] Tablets, the tablets are pulverized with a 20-mesh straight cylinder stainless steel sieve machine;

[0049] Add 15 g of magnesium stearate, mix uniformly, and compress into tablets to obtain plain tablets.

[0050] Take PVPS63060g, 95% ethanol 940g to prepare coating solution;

[0051] Put the plain tablets in the coating pan, and start spraying liquid when the temperature of the material in the coating pan reaches 35°C, and control the temperature of the material below 40°C during the entire coating process until all the spraying is completed;

[0052] After the coating is finished, the material is completely cooled and discharged.

Embodiment 2

[0054] Get lisinopril 50g, calcium hydrogen phosphate 200g, microcrystalline cellulose 225g, starch 125g, hydroxypropyl cellulose 50g, calcium sulfate 225g, carboxymethyl starch sodium 15g and hypromellose 2g, pass through a 30-mesh sieve;

[0055] Tablets, the tablets are pulverized with a 20-mesh straight cylinder stainless steel sieve machine;

[0056] Add 7.5 g of magnesium stearate, mix well, and tablet to obtain plain tablets.

[0057] Take 30g of PVPS630 and 470g of 95% ethanol to prepare coating solution;

[0058] Put the plain tablets in the coating pan, and start spraying liquid when the temperature of the material in the coating pan reaches 35°C, and control the temperature of the material below 40°C during the entire coating process until all the spraying is completed;

[0059] After the coating is finished, the material is completely cooled and discharged.

Embodiment 3

[0061] Get lisinopril 200g, calcium hydrogen phosphate 400g, microcrystalline cellulose 350g, starch 250g, hydroxypropyl cellulose 100g, calcium sulfate 450g, carboxymethyl starch sodium 30g and hypromellose 4g, cross 30 mesh sieves;

[0062] Tablets, the tablets are pulverized with a 20-mesh straight cylinder stainless steel sieve machine;

[0063] Add 15 g of magnesium stearate, mix uniformly, and compress into tablets to obtain plain tablets.

[0064] Take PVPS63060g, 95% ethanol 940g to prepare coating solution;

[0065] Put the plain tablets in the coating pan, and start spraying liquid when the temperature of the material in the coating pan reaches 35°C, and control the temperature of the material below 40°C during the entire coating process until all the spraying is completed;

[0066] After the coating is finished, the material is completely cooled and discharged.

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Abstract

The invention belongs to the technical field of medicines, and in particular to a stable lisinopril tablet and a preparation method thereof. The stable lisinopril tablet is prepared by dry granulation, and is coated, so that a series of adverse consequences resulting from moisture absorption of the tablet can be avoided, and the product quality is more stable.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a stable lisinopril tablet and a preparation method thereof. Background technique [0002] Lisinopril is a lysine derivative of enalaprilat, which belongs to the third generation of angiotensin-converting enzyme inhibitors, which can inhibit the activity of angiotensin-converting enzymes and reduce the concentration of angiotensin II and aldosterone , Elevate plasma renin activity, lead to peripheral vasodilation and decrease in vascular resistance, thus producing antihypertensive effect. [0003] The curative effect of this product is slightly better than atenolol or hydrochlorothiazide in the treatment of mild and moderate hypertension; the curative effect is the same as that of metoprolol or nifedipine in the treatment of severe hypertension; the treatment of congestive heart failure is better than Captopril, and can increase the left ventricular ejection fraction, enhance p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K9/28A61P9/12
Inventor 周莉花顾煜史红顾振洪
Owner SHANGHAI SINE WANXIANG PHARMA
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