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Method for extracting treatment ingredients for gastrointestinal disease from bark of liriodendron tulipifera

A technology of epimeilipidolactone, Liriodendron, applied in the field of preparation of extracts from the bark of Liriodendron tulipifera, which can solve the problem that the cause of gastritis and/or gastric ulcer has not been clearly disclosed, and the treatment method has not been developed , complex causes and other issues

Inactive Publication Date: 2014-10-29
CHO DANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the causes of gastritis and / or gastric ulcer have not been clearly disclosed due to the complex causes of gastritis and / or gastric ulcer
Therefore, no definitive treatment has been developed

Method used

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  • Method for extracting treatment ingredients for gastrointestinal disease from bark of liriodendron tulipifera
  • Method for extracting treatment ingredients for gastrointestinal disease from bark of liriodendron tulipifera
  • Method for extracting treatment ingredients for gastrointestinal disease from bark of liriodendron tulipifera

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preparation example Construction

[0036] The preparation method of the present application comprises 2 preparation steps: (1) a step of preparing an extract from the bark of Liriodendron tulipifera using a specific solvent of ethyl acetate or methylene chloride (method 1), (2) by increasing the step ( Purification step (method 2) to obtain a purified substance based on the amount of the component indicator in the extract obtained in 1).

[0037] In method 1, after the bark of Liriodendron tulipifera is chopped and powdered, extraction is performed using an extraction solvent selected from ethyl acetate or methylene chloride. After concentrating the extract, the obtained substance contains epituliprolactone and corylidene as active ingredients.

[0038] In Method 2, the extract obtained in Method 1 was dissolved using an aqueous alcohol solution. After adding hexane, lipid components and water-insoluble substances dissolved in hexane were removed. After the alcohol aqueous solution layer is separated, high-pu...

preparation example 1

[0057] Preparation Example 1: Using Ethyl Acetate to Obtain Extract

[0058] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 24 hours at 50°C. The resulting extraction mixture was concentrated and dried under reduced pressure. 6.83 g of extract was finally obtained. The amount of epituliprolactone was 3.96 wt%, and the amount of lignolide was 0.18 wt%.

preparation example 2

[0059] Preparation Example 2: Using Ethyl Acetate to Obtain Extract

[0060] 200 g of chopped and dried bark of Liriodendron tulipifera was extracted with 800 ml of ethyl acetate for 48 hours at 50°C. The resulting extraction mixture was concentrated and dried under reduced pressure. 7.67 g of extract was finally obtained. The amount of epituliprolactone was 3.94 wt%, and the amount of lignolide was 0.14 wt%.

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Abstract

The present invention relates to a method for extracting treatment ingredients for gastrointestinal diseases from the bark of Liriodendron tulipifera, the treatment ingredients containing epitulipinolide and costunolide as active ingredients, and to a therapeutic agent for gastrointestinal diseases, containing epitulipinolide and costunolide extracted using said method.

Description

technical field [0001] The present invention relates to a process for the preparation of an extract from the bark of Liriodendron tulipifera for use in the treatment of gastrointestinal disorders. Furthermore, the present invention relates to a therapeutic agent for treating gastrointestinal diseases, which contains epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera . Background technique [0002] It is reported that gastritis and / or gastric ulcer is the most common disease because about 10% of Koreans suffer from gastritis and / or gastric ulcer more than once in their lifetime. Gastritis and / or gastric ulcers are known to be caused by gastric acid digestion of the stomach wall comprising the mucosa, submucosa, muscularis externa and serosa. If only the gastric mucosa is damaged, it is called gastritis, while if the gastric submucosa and outer muscular layer are damaged, it is called gastric ulcer. In addition, an imbalance between aggressiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P1/04A61P1/00
CPCA61K36/57A61K31/365A61K2236/00A61P1/00A61P1/04A61K36/896
Inventor 金落斗
Owner CHO DANG PHARM
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