Therapy for subarachnoid hemorrhage and ischemia

Abstract

The application provides data from a clinical trial of a PSD-95 inhibitor in subjects undergoing endovascular repair of an aneurysm in or otherwise affecting the CNS. The subjects were stratified by whether the aneurysm ruptured before performing the endovascular surgery. Rupture is associated with higher mortality or increased debilitation if a subject survives. The trial provided evidence of significant benefit in subjects with and without aneurysm rupture before endovascular was surgery performed. Surprisingly, the subjects benefitting most from treatment as judged both by pathology and neurocognitive outcome were those in which the aneurysm had ruptured causing a subarachnoid hemorrhage. These data constitute evidence that a PSD-95 inhibitor is beneficial not only in ischemic and hemorrhagic stroke but in forms of hemorrhage in or affecting the CNS, particularly, subarachnoid hemorrhage.

Description

[0001] Cross References to Related Applications [0002] This application is a non-provisional patent application and is entitled to US 61 / 617,001 filed March 28, 2012, US 61 / 570,264 filed December 13, 2011, and filed on Priority of patent number CA 2762338 dated December 15, 2011. The entire contents of each of the above applications are incorporated by reference into this application. [0003] sequence listing [0004] This application includes a Sequence Listing submitted in American Standard Code for Information Interchange (ASCII) format to the EFS web online submission system, and the entire contents of this application are hereby incorporated by reference. A copy in ASCII format was generated on December 12, 2012 with the file name 427647SEQLIST.txt and a size of 15kb. Background technique [0005] About 800,000 people suffer from stroke in the United States every year, and the annual direct or indirect social loss reaches 40 billion US dollars. Stroke ranks third a...

AI Technical Summary

Problems solved by technology

Although the range of second-stage processes that may be involved in brain injury after subarachnoid hemorrhage is widely recognized, the exact role of a single mechanism during the acute injury period is not fully understood

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