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Method for acquiring characterization parameters of coronary disease

A technology for characterizing parameters and obtaining methods, applied in the medical field, can solve the problems of insufficient in-depth research on comprehensive genetic analysis of susceptibility to coronary heart disease, lack of accuracy, systematicness and integrity of effectiveness, etc.

Inactive Publication Date: 2014-09-17
西安时代基因健康科技股份有限公司
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Problems solved by technology

At the same time, there are not many in-depth studies on the comprehensive genetic analysis of susceptibility to coronary heart disease, and the early warning or intervention products related to the transformation of related technologies in the genetic health industry simply "copy" European and American ethnic data or public knowledge of health management, which lack accuracy, effectiveness, and systematization and integrity

Method used

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  • Method for acquiring characterization parameters of coronary disease
  • Method for acquiring characterization parameters of coronary disease

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Experimental program
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Effect test

Embodiment 1

[0043] 1) Establish a coronary heart disease susceptibility gene database:

[0044] 1.1) The name of the gene associated with coronary heart disease was preliminarily found on the GWAS website;

[0045] 1.2) In the Pubmed database of NCBI, the susceptibility genes related to Chinese coronary heart disease were screened out;

[0046] 1.3) Find the results of the association analysis related to the Chinese population, and determine the locus of the susceptibility gene obtained in step 1.2); the conditions to be satisfied for the association analysis related to the Chinese population are: the sample is a large sample population, and the source of the sample is Chinese population, or value greater than 1, 95% CI does not contain 1, and statistically significant; the large sample population includes at least 200 people.

[0047] 1.4) verify the locus of the susceptibility gene determined in step 1.3) in the SNP database of NCBI;

[0048] 1.5) Compiling a susceptibility gene colle...

Embodiment 2

[0068] 1. The client applies to the medical institution or physical examination institution, and fills in the genome testing and genetic analysis application form and the health questionnaire;

[0069] 2. Blood sample collection and storage;

[0070] 3. The samples are sent to the genetic testing laboratory;

[0071] 4. Carry out genetic testing according to the susceptibility gene detection combination sites in Table 1, and timely feedback the original data of genomic testing;

[0072] 5. Disease genetic risk analysis and in-depth genetic analysis of high-risk diseases;

[0073] 6. Comprehensive assessment of internal and external causes of high-risk diseases;

[0074] 7. Genome-guided personalized health management advice;

[0075] Among them, step 5, step 6 and step 7 are realized through an automated platform for genetic analysis of complex diseases. Professional genetic analysts will complete steps 5, 6 and 7 based on the results of genetic testing, and provide consul...

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Abstract

The invention discloses a method for acquiring characterization parameters of a coronary disease. The method comprises the following steps: 1) establishing a coronary disease susceptibility gene database; 2), establishing a characterization parameter analysis platform of an individual coronary disease according to the coronary disease susceptibility gene database established in the step 1); 3) analyzing the characterization parameters of the individual coronary disease on the basis of the analysis platform established in the step 2); 4) outputting the characterization parameters of the individual coronary disease. The method disclosed by the invention is capable of accurately acquiring characterization information in time and laying a foundation for sequential treatment work.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a method for acquiring parameters, in particular to a method for acquiring characteristic parameters of coronary heart disease. Background technique [0002] Coronary atherosclerotic heart disease refers to the heart disease caused by coronary atherosclerotic lesions leading to stenosis or blockage of blood vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis, collectively referred to as coronary heart disease (coronary heart disease), referred to as coronary heart disease, also known as ischemic heart disease (ischemic heart disease). Coronary atherosclerotic heart disease is the most common type of organ lesions caused by atherosclerosis, and it is also a common disease that seriously endangers human health. [0003] Coronary heart disease is relatively common in developed countries in Europe and the United States. About 500,000 people die from this disease in the...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06F17/30
Inventor 杨进孟涛赵锦荣赵东董靖张伟许嘉玲钱美睿牛彬彬徐博特贺红娟陈尔飞
Owner 西安时代基因健康科技股份有限公司
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