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Medicament composition for treating ischemic cerebrovascular disease and application thereof

A cerebrovascular disease and composition technology, applied in the field of medicine, can solve the problems of high price of therapeutic drugs, lack of effective therapeutic drugs, etc., and achieve good medical application prospects, significant therapeutic and preventive effects, and significant synergistic effects.

Inactive Publication Date: 2014-09-10
葛微
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the lack of effective therapeutic drugs for cerebral ischemia or cerebral infarction in the prior art and the high price of therapeutic drugs, the present invention provides a pharmaceutical composition capable of preventing or treating cerebral ischemia or cerebral infarction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Compound Pinocerin Alogliptin Tablets

[0020] Pinocerine 50g

[0021] Alogliptin 5g

[0022] Starch 25g

[0023] Dextrin 35g

[0024] Low-substituted hydroxypropyl cellulose 5g

[0025] 60% ethanol appropriate amount

[0026] Magnesium Stearate 1g

[0027] Preparation process: Weigh the prescribed amount of pinocerine, alogliptin starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 60% ethanol, add it to the mixed powder, mix it evenly to make a soft material, granulate it through a 16-mesh sieve, and dry it below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0028] Example 2 Preparation of Compound Pinocerin Alogliptin Tablets

[0029] Pinocerine 25g

[0030] Alogliptin 250g

[0031] Microcrystalline Cellulose 180

[0032] Hydroxypropyl Cellulose 15g

[0033] 8% starch slurry appropriate amount

[0034] Magnesium Stearate 1.5g

[0035]Preparation process: Weigh the prescribed amount of pinocerine, alogliptin, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0036] Example 3 Preparation of Compound Pinocerin Alogliptin Tablets

[0037] Pinocerine 25g

[0038] Alogliptin 75g

[0039] Starch 25g

[0040] Dextrin 35g

[0041] Low-substituted hydroxypropyl cellulose 5g

[0042] 60% ethanol appropriate amount

[0043] Magnesium Stearate 1g

[0044] Preparation process: Weigh the prescribed amount of pinocerine, alogliptin, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 60% ethanol, add it to the mixed powder, mix it evenly to make a soft material, granulate it through a 16-mesh sieve, and dry it below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention discloses a medicament composition for treating ischemic cerebrovascular diseases and an application thereof. The medicament composition uses pinocembrin and alogliptin as medicament active components, wherein the weight ratio between the two medicaments is preferably 1:(0.1-10), and is further preferably 1:1.5. The medicament composition has significant treatment and prevention effects on cerebral ischemia and cerebral infarction, and can be used for slowing down the conversion of cerebral ischemia into cerebral infarction diseases suffered by patients, reducing the sudden death rate of the patients suffering cerebral ischemia, improving the survival quality of the patients, and prolonging the survival time of the patients.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its use, in particular to a pharmaceutical composition with pinoxerine and alogliptin as active ingredients and its use in the preparation of drugs for treating ischemic cerebrovascular disease. It belongs to the field of medical technology. Background technique [0002] Ischemic cerebrovascular disease (ICVD) accounts for about 80% of all cerebrovascular diseases. It has the characteristics of high morbidity, disability and cure rate, and has become one of the diseases that seriously affect human health. Ischemic cerebrovascular disease is one of the most important diseases in cerebrovascular diseases. It is a sudden imbalance between the supply and demand of oxygen and other nutrients provided by the local blood circulation and the metabolic needs of neurons, which eventually leads to the central area of ​​ischemia. A class of diseases in which neurons are damaged. Transient ischemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61P9/10A61K31/352
Inventor 强红枫
Owner 葛微
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