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Fluorescent quantum dot for magnetic resonance imaging, and preparation method thereof

A technology of fluorescent quantum dots and magnetic resonance imaging, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, chemical instruments and methods, etc., and can solve problems such as unstable structures of complexes, toxic side effects, etc. , to achieve the effects of easy scale-up production, low biological toxicity and low cost

Inactive Publication Date: 2014-09-03
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the contrast agents used clinically are the former, and most of them use complexes of rare earth element Gd. Since the structure of the complex is not very stable, a large amount of non-essential Gd elements will inevitably bring some toxic and side effects

Method used

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  • Fluorescent quantum dot for magnetic resonance imaging, and preparation method thereof
  • Fluorescent quantum dot for magnetic resonance imaging, and preparation method thereof
  • Fluorescent quantum dot for magnetic resonance imaging, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] First, 5ml of octadecene, 0.1mmol of silver acetate, 0.1mmol of zinc acetate, 0.1mmol of indium acetate and 0.01mmol of gadolinium chloride, 0.6mmol of oleic acid and 0.6mmol of dodecyl mercaptan were added to the reaction flask, and then the solution was heated to 160 ℃, 0.3mmol elemental sulfur was dissolved in 0.3ml oleylamine and quickly injected into the above reaction solution and kept for 20 minutes to prepare GdZnAgInS with a Gd:Ag ratio of 1:10 and a particle size of 3nm 3 quantum dots.

Embodiment 2

[0027] First, 50ml of octadecene, 1mmol of silver acetate, 1mmol of zinc acetate, 1mmol of indium acetate, 0.00625mmol of gadolinium chloride, 6mmol of oleic acid and 6mmol of dodecyl mercaptan were added to the reaction flask, then the solution was heated to 180°C, and 3mmol of elemental sulfur Dissolved in 3ml of oleylamine and quickly injected into the above reaction solution and kept for 20 minutes to prepare GdZnAgInS with a Gd:Ag ratio of 1:160 and a particle size of 4.6nm 3 quantum dots.

Embodiment 3

[0029] First, 20ml of octadecene, 0.4mmol of silver acetate, 0.4mmol of zinc acetate, 0.4mmol of indium acetate and 0.01mmol of gadolinium chloride, 2.4mmol of oleic acid and 2.4mmol of dodecyl mercaptan were added to the reaction flask, and then the solution was heated to 210 ℃, 1.2mmol elemental sulfur was dissolved in 1.2ml oleylamine and quickly injected into the above reaction solution and kept for 20 minutes to prepare GdZnAgInS with a Gd:Ag ratio of 1:40 and a size of 6nm 3 quantum dots.

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Abstract

The invention belongs to the technical field of semiconductor nanomaterial preparation and a medical material, and relates to a fluorescent quantum dot for magnetic resonance imaging, and a preparation method thereof. The specific structure of the quantum dot is Gd@ZnAgInS3. The preparation method comprises the following steps: firstly, dissolving silver acetate, zinc acetate, indium acetate, gadolinium chloride, oleic acid and lauryl mercaptan into octadecene, increasing the temperature to 160-210DEG C, then injecting an oleylamine solution of sulfur, and maintaining for 20 minutes. The prepared quantum dot has double functions, not only can be used as a magnetic resonance imaging contrast medium, but also has the fluorescent property adjustable from the visible light to near infrared wavebands, and also has the characteristics of being low in toxicity, high in stability and the like; the preparation method is simple, and environmental friendly.

Description

technical field [0001] The invention belongs to the technical field of semiconductor nanomaterial preparation and medical materials, and in particular relates to a fluorescent quantum dot for magnetic resonance imaging and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) technology is an innovative medical imaging diagnostic technology that has gradually developed since the early 1980s. Compared with traditional CT detection technology and nuclide imaging (PET) technology, MRI technology has broader application prospects. At present, this technology has been widely used clinically, but it cannot give enough sensitivity and accuracy test results for the early diagnosis of most diseases. The most direct way to solve this problem is to choose a suitable MRI contrast agent. , under the influence of the contrast agent, the relaxation time of some water molecules around the human tissue will be changed, so as...

Claims

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Application Information

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IPC IPC(8): C09K11/62C09K11/02A61K49/00A61K49/06
Inventor 王博蔚李冬泽张颖解仁国
Owner JILIN UNIV
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