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Biopharmaceutical wastewater treatment method

A biopharmaceutical and wastewater treatment technology, applied in heating water/sewage treatment, chemical instruments and methods, cleaning methods and utensils, etc., can solve the problems of high steam energy consumption, secondary pollution, long time, etc., and achieve good technical results , Low steam consumption and easy cleaning

Active Publication Date: 2016-05-11
SINOPEC SHANGHAI ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is that the existing technology has intermittent operation, long time, large energy consumption of steam; easy to cause secondary pollution; and the problem that the sterilization end point cannot be effectively controlled, and a new biopharmaceutical wastewater treatment method is provided.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Recombinant human growth hormone rhGH is produced by using Escherichia coli as a raw material, through inoculation, cultivation, screening and other steps, to obtain qualified strains, and then fermentation, separation, freeze-thaw lysis, extraction, separation, and purification. . As the production process uses Escherichia coli as an engineering bacteria, the wastewater discharged from the production process (including liquid preparation wastewater, equipment site cleaning wastewater, etc.) contains Escherichia coli, which has biological activity, and heat sterilization is now used to remove its activity.

[0036] The above wastewater is continuously transported to the ultra-high temperature sterilizer. The ultra-high temperature sterilizer uses saturated industrial steam for heating, which makes the microbial protein coagulate and denature, thereby losing its original biological activity.

[0037] In the ultra-high temperature sterilizer, jacket heating is used, the tempe...

Embodiment 2

[0042] Same as [Example 1], except that the outlet temperature of the high-temperature sterilizer is 120°C, the temperature of the heat preservation device is 120°C, and the residence time in the heat preservation zone is 5 seconds.

[0043] Daily production of pharmaceutical wastewater 9m 3 , Processing 1m per hour 3 Biological wastewater is heated by 0.2MPa, 133℃ saturated industrial steam, the heating steam consumption is 198kg / h, and the heat exchange area is 4.0m 2 . After each treatment of the waste liquid for 45 minutes, the cleaning solution containing the cleaning balls is passed for 15 minutes to clean the inner wall of the heat exchange tube.

[0044] The method can be operated continuously, and the heating steam does not directly contact the wastewater, and will not cause secondary pollution. The ultra-high temperature sterilizer can be used continuously for more than 10 days (80 hours) without disassembly and cleaning.

Embodiment 3

[0046] Same as [Example 1], the outlet temperature of the high temperature sterilizer is 115°C, the temperature of the heat preservation equipment is 112°C, and the residence time in the heat preservation zone is 8 seconds. Only the diameter of the spiral heat exchange tube d=25mm, the spiral diameter D=300mm, d:D=1:12, the length of the heat exchange tube in each zone L=57m, and the total residence time is 100 seconds. The pitch of the spiral tube is h=32mm, d:h=1:1.25, the inner diameter of the shell side D1=250mm, the outer diameter D2=350mm, and the total length of the heat exchanger is 2.2m. The diameter of the cleaning ball is d1=5mm, d1:d=1:5.

[0047] Daily production of pharmaceutical wastewater 9m 3 , Processing 1m per hour 3 Biological wastewater is heated by 0.1MPa, 121℃ saturated industrial steam, the heating steam consumption is 209kg / h, and the heat exchange area is 5.4m 2 . After 80 minutes of each waste liquid treatment, the cleaning solution containing cleaning...

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Abstract

The invention relates to a method for treating biological pharmaceutical wastewater. The problems that the intermittent operation time is long, steam energy consumption is high, secondary pollution is easily caused and the sterilization endpoint cannot be effectively controlled in the prior art are mainly solved. The method comprises the following steps: (a) allowing biological pharmaceutical wastewater containing microbial active ingredients to continuously pass through an ultrahigh temperature sterilizer tube pass, and obtaining wastewater of which the biological activity is removed; (b) allowing a cleaning solution containing a cleaning ball to continuously pass through the ultrahigh temperature sterilizer tube pass; and (c) alternatively performing the step (a) and the step (b). According to the technical scheme that the alternate frequency is controlled by an automatic control system, the problems are well solved, and the method can be used for industrial production of the biological pharmaceutical wastewater containing microbial active ingredients, of which the biological activity is removed.

Description

Technical field [0001] The invention relates to a biological pharmaceutical wastewater treatment method. Background technique [0002] Biomedicine technology is based on modern life science theories, using organisms and their components, through genetic engineering, cell engineering, fermentation engineering, enzyme engineering and other biotechnological means to develop and produce comprehensive technologies for medical products. Because the traditional chemical new drug research and development is facing the situation of increasing difficulty, rising cost, continuously extending cycle, and decreasing success rate, at the same time, due to the continuous development and progress of biotechnology, especially the completion of the human genome project, people's attention Gradually pay attention to the field of biotechnology, so that the biomedical industry has made considerable progress. [0003] Since biomedical technology mainly uses organisms and their components, and uses moder...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F1/02B08B9/057
Inventor 杨军李陈江
Owner SINOPEC SHANGHAI ENG
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