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A compound preparation for preventing and treating osteoporosis and its preparation method

A technology for osteoporosis and compound preparations, which is used in medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc.

Active Publication Date: 2015-12-02
高益槐 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no safe and effective radical cure in medicine to help the loose bones return to their original state. Therefore, correct understanding and early prevention are particularly important.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] The preparation method comprises the following steps:

[0068] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder

[0069] After the raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection are pretreated, they are extracted twice with 10 times the amount of 70wt.% ethanol solution under reflux, each time for 1 hour, and the two extracts are combined and filtered; Under the conditions of 80°C and vacuum degree of -0.04~-0.06MPa, concentrate to the extract with a relative density of 1.20 at 60°C; The paste is pulverized with an 80-mesh sieve to obtain the extract powder of Epimedium and Achyranthes bidentata;

[0070] (2) Calcium citrate, casein phosphopeptide and magnesium stearate are sieved

[0071] Calcium citrate, casein phosphopeptide, and magnesium stearate selected through quality standard inspection were passed through 80-mesh sieves;

[0072] (3) mixed

[0073] After mixing Epimedium...

Embodiment 1

[0077] The raw material composition and mass fraction of a compound preparation for preventing and treating osteoporosis: Epimedium 25%, Achyranthes bidentata 19%, calcium citrate 46%, casein phosphopeptide 8%, magnesium stearate 2%.

[0078] The preparation method comprises the following steps:

[0079] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder

[0080] After pretreatment, the raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection were extracted twice with 10 times the amount of 70wt.% ethanol solution, 1 hour each time, and the two extracts were combined and filtered; at a temperature of 60 ° C 1. Under the condition of vacuum degree -0.04MPa, concentrate to 60°C with a relative density of 1.20 extract; under the condition of temperature 60°C and vacuum degree -0.08MPa, dry to a water content below 5%; use an 80-mesh sieve to dry the extract Pulverize to get Epimedium and Achyranthes bid...

Embodiment 2

[0088] The raw material composition and mass fraction of a compound preparation for preventing and treating osteoporosis: Epimedium 24%, Achyranthes bidentata 20%, calcium citrate 45%, casein phosphopeptide 9%, magnesium stearate 2%.

[0089] The preparation method comprises the following steps:

[0090] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder

[0091] The raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection are pretreated, extracted twice with 10 times the amount of 70wt.% ethanol solution under reflux, and each time for 1 hour, the two extracts are combined and filtered; 1. Under the condition of vacuum degree -0.06MPa, concentrate to 60°C with a relative density of 1.20 extract; under the condition of temperature 60°C and vacuum degree -0.08MPa, dry it to a water content below 5%; use an 80-mesh sieve to dry the extract Pulverize to get Epimedium and Achyranthes bidentata extract po...

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Abstract

The invention provides a compound preparation for preventing and treating the osteoporosis and a preparation method thereof. The compound preparation consists of herba epimedii, radix achyranthis bidentatae, calcium citrate, casein phosphopeptides and magnesium stearate. The preparation method comprises the following steps: preparing powder by extracting the materials of the herba epimedii and the radix achyranthis bidentatae, sieving the calcium citrate, the casein phosphopeptides and the magnesium stearate, blending, mixing, granulating, metering, filling into capsules and packaging. The compound preparation and the preparation method provided by the invention have the advantages that elaborate prescription is adopted on the basis of the traditional theory of traditional Chinese medicine and the modern pharmacological research, the herba epimedii and the radix achyranthis bidentatae have the effects of nourishing liver and kidney and strengthening the muscles and bones; and by combination of the casein phosphopeptides and the calcium citrate, the absorption and utilization of calcium can be better enhanced, the calcium content in bones can be improved and the density of the bones can be increased, so that the two effects of increasing the density of the bones and preventing and treating the osteoporosis are achieved. A product prepared by the compound preparation not only is safe in administration and has obvious preventing and treating effects and health-care effect, but also is low in industrial production cost and has a good prospect for market development and application.

Description

technical field [0001] The invention belongs to the field of medicine and health food, and in particular relates to a compound preparation for preventing and treating osteoporosis and a preparation method thereof. Background technique [0002] Bone mineral density (bone mineral density, BMD) is an important marker of bone quality, reflecting the degree of osteoporosis, and an important basis for predicting osteoporotic fractures. [0003] Human bone density peaks at around 30 years old and then declines year by year due to bone loss. Women lose bone faster than older men after menopause. According to reports, regardless of men and women, after the age of 60, bone loss generally reaches 20% to 30% of the peak value, and the maximum can reach 40%. Osteoporosis has become one of the global public health problems, and it has been paid more and more attention by people. At present, the total number of people suffering from osteoporosis in the world is more than 200 million. As ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K47/42A61P19/10A61K31/194A61K36/296A61K36/21
Inventor 高益槐
Owner 高益槐
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