Compound preparation for preventing and treating osteoporosis and preparation method thereof
A technology for osteoporosis and compound preparations, which is used in medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc.
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preparation example Construction
[0067] The preparation method comprises the following steps:
[0068] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder
[0069]After the raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection are pretreated, they are extracted twice with 10 times the amount of 70wt.% ethanol solution under reflux, each time for 1 hour, and the two extracts are combined and filtered; Under the conditions of 80°C and vacuum degree of -0.04~-0.06MPa, concentrate to the extract with a relative density of 1.20 at 60°C; The paste is pulverized with an 80-mesh sieve to obtain the extract powder of Epimedium and Achyranthes bidentata;
[0070] (2) Calcium citrate, casein phosphopeptide and magnesium stearate are sieved
[0071] Calcium citrate, casein phosphopeptide, and magnesium stearate selected through quality standard inspection were passed through 80-mesh sieves;
[0072] (3) mixed
[0073] After mixing Epimediu...
Embodiment 1
[0077] The raw material composition and mass fraction of a compound preparation for preventing and treating osteoporosis: Epimedium 25%, Achyranthes bidentata 19%, calcium citrate 46%, casein phosphopeptide 8%, magnesium stearate 2%.
[0078] The preparation method comprises the following steps:
[0079] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder
[0080] After pretreatment, the raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection were extracted twice with 10 times the amount of 70wt.% ethanol solution, 1 hour each time, and the two extracts were combined and filtered; at a temperature of 60 ° C 1. Under the condition of vacuum degree -0.04MPa, concentrate to 60°C with a relative density of 1.20 extract; under the condition of temperature 60°C and vacuum degree -0.08MPa, dry to a water content below 5%; use an 80-mesh sieve to dry the extract Pulverize to get Epimedium and Achyranthes bid...
Embodiment 2
[0088] The raw material composition and mass fraction of a compound preparation for preventing and treating osteoporosis: Epimedium 24%, Achyranthes bidentata 20%, calcium citrate 45%, casein phosphopeptide 9%, magnesium stearate 2%.
[0089] The preparation method comprises the following steps:
[0090] (1) Extraction of Epimedium and Achyranthes bidentata raw materials to make powder
[0091] The raw materials of Epimedium and Achyranthes bidentata selected through the quality standard inspection are pretreated, extracted twice with 10 times the amount of 70wt.% ethanol solution under reflux, and each time for 1 hour, the two extracts are combined and filtered; 1. Under the condition of vacuum degree -0.06MPa, concentrate to 60°C with a relative density of 1.20 extract; under the condition of temperature 60°C and vacuum degree -0.08MPa, dry it to a water content below 5%; use an 80-mesh sieve to dry the extract Pulverize to get Epimedium and Achyranthes bidentata extract po...
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