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A Multifunctional Imaging Probe for Detecting Mercury Ions

A technology of imaging probes and mercury ions, which is applied in measuring devices, nuclear magnetic resonance analysis, instruments, etc., can solve the problems of low sensitivity and poor imaging targeting, and achieve the goal of avoiding poor tissue penetration and compensating for low sensitivity Effect

Inactive Publication Date: 2016-11-23
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current magnetic resonance imaging technology is facing application bottlenecks, that is, low sensitivity and poor targeting of contrast imaging.

Method used

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  • A Multifunctional Imaging Probe for Detecting Mercury Ions
  • A Multifunctional Imaging Probe for Detecting Mercury Ions
  • A Multifunctional Imaging Probe for Detecting Mercury Ions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] a Rhodamine B was dissolved in ethanol, five times the molar amount of ethylenediamine was added to the solution, heated to 80°C under stirring, and after four hours of reaction, the reaction solution was allowed to stand, filtered by suction, and dried under reduced pressure to obtain a white solid , yield 90%, HRMS 484.2838;

[0023]

[0024] b Dissolve the white solid obtained in step a in DMF solution, add 0.5 times the molar amount of DTPA, heat in an oil bath at 100 degrees for six hours, evaporate DMF under reduced pressure, and dry under reduced pressure to obtain a white solid with a yield of 95%. , HRMS 1325.6849;

[0025]

[0026] c Dissolve the white solid obtained in step b and an equimolar amount of gadolinium nitrate in methanol, stir at room temperature for 24 hours, and dry under reduced pressure to obtain the target product with a yield of 95%. TOF-ESI-MS: calcd for [C74H88GdN11O12+2H ] 2+ : m / z 741.2997, found m / z 741.0806; calcd f...

Embodiment 2

[0028]

[0029] Rhodamine B is used instead of Rhodamine 6G in the process a, the rest is the same as Example 1, TOF-ESI-MS: calcd for[C70H80GdN11O12+2H] 2+ : m / z 713.2615, found m / z 713.2623.

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Abstract

The invention relates to a multi-functional imaging probe for mercury ion detection. The probe has the following structural general formula shown in the specification, when in preparing, an equimolar amount of rhodamine as a raw material and quintuple of ethanediamine are heated in ethanol for reacting to obtain a white solid; then the white solid and diethylenetriamine pentaacetic acid dianhydride are further heated in a dimethylformamide solution for reacting and then drying under reduced pressure to obtain a product, the obtained product and gadolinium nitrate are stirred in a methanol solution at room temperature overnight, and then a target product is obtained by drying under reduced pressure. The probe molecule is good in chemical and light stability, easy to dissolve in water and high in mercury ion selective, is not affected by other metal ion interference in organisms, and can realize high sensitivity fluorescence imaging and high spatial resolution magnetic resonance imaging of mercury ions.

Description

technical field [0001] The invention relates to a class of multifunctional imaging molecular probes for detecting mercury ions by fluorescence imaging and magnetic resonance imaging. Background technique [0002] Due to the high chemical reactivity of mercury, it can associate with functional groups such as carboxyl, sulfhydryl and phosphate groups in biomolecules such as enzymes, proteins and nucleic acids in the body, which seriously interferes with life processes such as neuron transmission and cell division. , poses a huge threat to human health. However, the mechanism of mercury in living organisms has not yet been clearly understood. Therefore, an effective mercury element analysis and detection method, especially a mercury element detection method that can integrate multiple imaging methods in multiple directions and layers, will help us further understand the mechanism of mercury element, so as to avoid the harm of mercury and the control of pollution sources Manag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D519/00C09K11/06G01N21/64G01N24/08
CPCC07D519/00C09K11/06C09K2211/1029C09K2211/1077G01N21/6456G01N24/08
Inventor 张晓琳
Owner DALIAN UNIV
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