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Pharmaceutical composition for treating climacteric vaginal bleeding and preparation method thereof

A technology of vaginal bleeding and composition, which is applied in the application field of medicine, can solve the problems of unreported Kuntai Capsule vaginal bleeding, etc., and achieve the effect of benefiting rehabilitation

Active Publication Date: 2016-01-20
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Based on the knowledge of the inventors, there is currently no report that the combination of Kuntai Capsules and Mifepristone is more effective in preventing, alleviating and / or treating menopausal vaginal bleeding in women

Method used

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  • Pharmaceutical composition for treating climacteric vaginal bleeding and preparation method thereof
  • Pharmaceutical composition for treating climacteric vaginal bleeding and preparation method thereof
  • Pharmaceutical composition for treating climacteric vaginal bleeding and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: capsule type preparation

[0047] a.

[0048] active agent Amount added (g) Kuntai Capsules 200 excipient

starch 200 Magnesium stearate 3

[0049] The Kuntai capsule composition used in the embodiment of the present invention can be the Kuntai capsule of the purchased medicine, and its ingredients are poured out from the capsule. Or the ratio of each component of Kuntai capsule purchased from a Chinese herbal pharmacy. Weigh 143g Rehmannia glutinosa, 35g Coptis chinensis, 13g Radix Paeoniae Alba, 3.5g Scutellaria baicalensis, 2.5g donkey-hide gelatin, and 3.0g Poria cocos, and grind them into fine powder. The component is passed through a 120 mesh sieve, weighed, added the amount of starch and magnesium stearate in the above table to mix, and then poured into the lower hopper. Turn on the granulation coating machine, the air inlet pressure is 0.6bar, the air inlet temperature is 30℃, the spray gun pressure (CYL) ...

Embodiment 2

[0054] Embodiment 2 tablet preparation a,

[0055] active agent Amount added (g) Kuntai Capsules 300 excipient

Cassava starch 30 Galactose 20 microcrystalline cellulose 30

[0056] Preparation process: Weigh the components of Kuntai Capsules respectively: Rehmannia glutinosa 214g, Coptidis 53g, Radix Paeoniae Alba 20g, Scutellaria baicalensis 5.5g, Donkey-hide gelatin 3.0g, Poria cocos 4.5g, pass through a 100 mesh sieve, tapioca starch, galactose, microcrystalline cellulose Pass through an 80-mesh sieve, mix well, add 100g of 6% PVP absolute ethanol solution to granulate in an appropriate amount, dry at 60°C, shape the dry granules through a 18-mesh sieve, and add 2g of magnesium stearate to the dry granules.

[0057] b.

[0058] active agent Amount added (g) mifepristone 1.0 excipient

starch 50 Maltitol 50 Xylose 40 Micro silica gel 5

[0059] Preparation process: mifepris...

Embodiment 3

[0061] Embodiment 3. mixed capsule type controlled release preparation

[0062] a. Preparation of active drug core

[0063] active agent Amount added (g) Kuntai Capsule Components 200 mifepristone 1.0g excipient

starch 200 Magnesium stearate 3 Adhesive

glucose 2 Maltodextrin 3 vinyl acetate copolymer 1.5

[0064] The Kuntai capsule component or mifepristone used in the embodiments of the present invention can be the purchased medicine Kuntai capsule, and its components are poured out from the capsule. Or buy it from a Chinese herbal pharmacy, weigh the components of Kuntai capsules: 214g Rehmannia glutinosa, 53g Coptis chinensis, 20g Radix Paeoniae Alba, 5.5g Scutellaria baicalensis, 3.0g donkey-hide gelatin, 4.5g Poria cocos, and grind them into fine powder. Pass the component through a 120-mesh sieve, weigh it, add starch, magnesium stearate, glucose, maltodextrin and vinyl acetate copolymer in the a...

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Abstract

The invention provides medicine composition for treating colporrhagia in woman climacterium. The medicine composition comprises a first active component, namely, components of a Kuntai capsule and a second active component, namely, mifepristone, wherein the Kuntai capsule comprises cooked rehmannia roots, rhizoma coptidis, radix paeoniae alba, radix scutellariae, ass-hide glue and poria cocos. Through combined application of the Kuntai capsule and the mifepristone of the composition, the composition is obvious superior to a singleprescription of the same dosage in effect of treating the colporrhagia in the woman climacterium, the fact indicates that the two medicines have synergistic effects when being combined for usage, and meanwhile, the composition is free of obvious toxicity and side effects and more significant in treatment effect.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating menopausal vaginal bleeding, more specifically, the present invention also relates to the preparation method of the composition and the application of the medicine prepared by the preparation method in the medicine for treating women's menopausal vaginal bleeding . Background technique [0002] Vaginal bleeding occurs during menopause, and dizziness, numbness of limbs, hand tremor, memory loss, sleepiness, irritability, agitation, decreased adaptability and increased sensitivity often occur in different individuals. In severe cases, it can be life-threatening. [0003] Kuntai Capsule is made of Rehmannia glutinosa, Coptis chinensis, Radix Paeoniae Alba, Scutellaria baicalensis, donkey-hide gelatin, and Poria cocos. For those with hyperactivity of fire due to deficiency of yin, the symptoms include hot flashes, flushed face, spontaneous sweating, restlessness, insomnia and drea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P15/12A61P7/04A61K35/36A61K31/567
Inventor 段燕康李瑞霞黄晓昱张杰
Owner GUIYANG XINTIAN PHARMA CO LTD
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