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N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof

A phthalimide and alkylation technology, which is applied in the direction of botany equipment and methods, chemical instruments and methods, applications, etc., can solve the problems of increased cost of agricultural products, decreased crop productivity, and damage to agricultural products, and achieves high Effects of controlling invertebrate pests, reducing crop production costs and environmental load

Inactive Publication Date: 2014-07-16
GUILIN JIQI BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Invertebrate pests harm the growth of crops, cause a decrease in crop productivity, damage stored agricultural products, and increase the cost of agricultural products

Method used

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  • N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof
  • N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof
  • N-alkylation phthalimide piperazine derivatives as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0151] A synergistic composition, its active ingredient contains component (a) and component (b), wherein said component (a) is the compound of formula I, and component (b) is a kind of selected from (b1) new A neonicotinoid pest control agent, wherein the mass ratio of the component (a) to the component (b) is 25:1-1:20.

Embodiment 2

[0153] A synergistic composition comprising component (a) and component (b), wherein said component (a) is a compound of formula I, and component (b) is a choline ester selected from (b2) An enzyme inhibitor, and the mass ratio of the component (a) to the component (b) is 30:1-1:15.

Embodiment 3

[0155] A synergistic composition, its active ingredient contains component (a) and component (b), wherein said component (a) is the compound of formula I, and component (b) is a kind of selected from (b3) GABA An adjusted chloride ion channel blocker, and the mass ratio of the component (a) to the component (b) is 30:1-1:20.

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PUM

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Abstract

The invention discloses N-alkylation phthalimide piperazine derivatives as well as a preparation method and an application thereof. The structural formula of the N-alkylation phthalimide piperazine derivatives is shown in descriptions, and in the structural formula, n is 1 or 2 or 3. The preparation method of the N-alkylation phthalimide piperazine derivatives comprises the following steps: dissolving phthalimide potassium salt in acetone, then adding dibromine alkane to the acetone, and reacting for 5-12 hours at the temperature of 45-65 DEG C so as to obtain a first intermediate; dissolving piperazine in dichloromethane, adding diethyl thiophosphoryl chloride to the dichloromethane at the temperature of -5 to 5 DEG C, and reacting for 0.1-1 hour at the temperature of -5 to 5 DEG so as to obtain a second intermediate; and dissolving the first intermediate in N,N-dimethylformamide, adding monovalent carbonate and the second intermediate to the N,N-dimethylformamide, and reacting for 1-5 hours at the temperature of 50-80 DEG C. The N-alkylation phthalimide piperazine derivatives provided by the invention have high effect on prevention and treatment of invertebrate insect pests. Serving as arthropod killing agents, the N-alkylation phthalimide piperazine derivatives are capable of reducing production cost and environmental load.

Description

technical field [0001] The invention relates to the field of pest control, in particular to an N-alkylated phthalimide piperazine derivative and a preparation method and application thereof. Background technique [0002] Invertebrate pests harm the growth of crops, reduce crop productivity, destroy agricultural products in storage, and increase the cost of agricultural products. Therefore, controlling invertebrate pests is extremely important to improve crop yield and quality. Invertebrate pests also affect forestry production, greenhouse crops, ornamental plants, livestock, household products, public health and animal hygiene, therefore, the control of invertebrate pests in non-agronomic environments is also very important. [0003] Many products for controlling invertebrate pests are commercially available and can be used alone or as a mixture in production. However, as people pay more and more attention to the environment, it is more and more urgent to seek more economi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6558A01N57/32A01N63/04A01N63/00A01P7/02A01P7/04A01N47/40A01N47/24A01N47/22A01N43/24A01N47/02A01N53/06A01N53/08A01N47/38A01N47/12
Inventor 梅向东张兰祥宁君张涛董梦雅司伟杰
Owner GUILIN JIQI BIOCHEM
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