A colorimetric method for the rapid detection of folate-overexpressing cancer cells
A detection method, a cancer cell technology, is applied in the direction of material analysis by observing the influence of chemical indicators, and analysis by making materials undergo chemical reactions. It can solve the difficult research progress, limited application and popularization of cell detection methods, Expensive analysis costs and other issues, to achieve good folate receptor targeting, strong connection, and improved selectivity
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[0027] Example 1 is used for the rapid detection method of K562 tumor cells
[0028] 1 Preparation of folic acid / AuPtPd nanomaterials
[0029] (1) Measure 80mL of deionized water into a three-neck flask, heat to 90°C, add 0.8mL of 1% HAuCl 4 , heated to 96°C and kept for one minute, then added 2.8mL of 1% sodium citrate, continued to stir for 15min, and naturally cooled to room temperature; weighed 0.048gK 2 PtCl 6 In 50mL water, 0.035gPdCl 2 Dissolve in 2mL of 0.2mol / L hydrochloric acid and dilute to 100mL with water; take 5mL of gold nano solution and 40μL of 2mmol / LK 2 PtCl 6 and 40μL 2mmol / LH 2 PdCl 4 The solutions were mixed, 10 times the amount of ascorbic acid was added, and the solution was shaken vigorously, the color of the solution changed from brown to gray.
[0030](2) 6-mercapto-hexanol, azide-11-alkyl-thiol and AuPtPd were mixed according to the mass ratio of 20:10:1, and the resulting solution was placed at 25°C for 72 hours, and a semipermeable solution...
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