Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof

A technology of interpenetrating network structure and three-dimensional scaffold is applied in the field of osteochondral three-dimensional scaffold and its preparation, which can solve the problem that the mechanical strength of the scaffold is not taken into account, and achieve the effect of a large control range.

Inactive Publication Date: 2015-07-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Through comparison, it can be found that the existing design of osteochondral integrated tissue engineering scaffolds mainly focuses on the mechanical strength of the scaffold and the functionality of the scaffold, so there are many problems to be solved in the designed integrated repair scaffold

Method used

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  • Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof
  • Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof
  • Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof

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Embodiment 1

[0035] Osteochondral three-dimensional scaffold with regular interpenetrating network structure in this embodiment: a regular interpenetrating network structure is formed by biomedical polymer material system and in-situ generated hydrogel material system, including calcification layer, radiation layer, transition layer and In the shallow surface layer, each layer is connected to each other, and the internal pores are square. The thickness of the calcification layer is 100 μm, the thickness of the radiation layer is 1000 μm, the thickness of the transition layer is 500 μm, and the thickness of the superficial layer is 100 μm. The pore size of the calcified layer and the radioactive layer is 50 μm, and that of the transition layer and superficial layer is 20 μm.

[0036] Among them, the biomedical polymer material system is composed of polyurethane and hydroxyapatite. The content of polyurethane in the biomedical polymer material system of the calcification layer is 70wt%, and ...

Embodiment 2

[0044] Osteochondral three-dimensional scaffold with regular interpenetrating network structure in this embodiment: a regular interpenetrating network structure is formed by biomedical polymer material system and in-situ generated hydrogel material system, including calcification layer, radiation layer, transition layer and The superficial layer, each layer is connected with each other, including the calcified layer, the radiation layer, the transition layer and the shallow surface layer, the layers are connected with each other, and the internal holes are square. The thickness of the calcified layer is 1500 μm, the thickness of the radioactive layer is 3000 μm, the thickness of the transition layer is 2000 μm, and the thickness of the superficial layer is 3000 μm. The pore diameter of the calcification layer and the radiation layer is 500 μm, and the transition layer and superficial layer and the pore diameter are set as 800 μm.

[0045] Among them, the biomedical polymer mat...

Embodiment 3

[0054] Osteochondral three-dimensional scaffold with regular interpenetrating network structure in this embodiment: a regular interpenetrating network structure is formed by biomedical polymer material system and in-situ generated hydrogel material system, including calcification layer, radiation layer, transition layer and In the shallow surface layer, each layer is connected to each other, and the internal pores are square. The thickness of the calcified layer is 500 μm, the thickness of the radioactive layer is 2000 μm, the thickness of the transition layer is 1500 μm, and the thickness of the superficial layer is 2500 μm. The pore structure inside the scaffold is set to be square; the pore diameter of the calcification layer and the radiation layer is set to 450 μm, and the transition layer and superficial layer and the pore diameter are set to 200 μm.

[0055] Among them, the biomedical polymer material system is composed of polycaprolactone and tricalcium phosphate; the ...

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Abstract

The invention discloses an osteochondral three-dimensional stent with a regular interpenetrating network structure. A biological medical high polymer material system and an in-situ generated hydrogel material system form the regular interpenetrating network structure. The osteochondral three-dimensional stent is provided with a multi-layer structure which is divided into a calcified layer, a radiation layer, a transition layer and a superficial layer. The invention further discloses a preparation method of the osteochondral three-dimensional stent. By virtue of a 3D (Three-dimensional) printing technology, the biological medical high polymer material system and the in-situ generated hydrogel material system inside the stent form the interpenetrating network structure. As a novel integral joint osteochondral three-dimensional stent, the osteochondral three-dimensional stent disclosed by the invention is combined with mechanical performance and functional requirements of the stent, can effectively promote repair of each area of the cartilage and can finally achieve an integral repair purpose of the cartilage.

Description

technical field [0001] The invention relates to a three-dimensional osteochondral scaffold and a preparation method thereof, in particular to a three-dimensional osteochondral scaffold with a regular interpenetrating network structure and a preparation method thereof. Background technique [0002] In the 1990s, American scholars Vacant and Langer proposed the concept of regenerative medicine of tissue engineering, and now a new discipline of tissue engineering has gradually formed. Tissue engineering is the use of the principles and methods of life science and engineering to research and develop a new generation of clinically applied substitutes that can repair or improve the functions of human tissues or organs, and are used to replace part or all of the functions of tissues or organs. The development of tissue engineering also provides another way for the repair of cartilage damage, especially in solving the problem of the source of transplanted tissue, combining cytokines...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/10A61L27/12A61L27/02A61L27/08A61L27/52A61L27/54A61L27/56
Inventor 吴刚王磊郭琳陈龙
Owner SOUTH CHINA UNIV OF TECH
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