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Application of chrysin in preparing anti-hypoxic drug

An anti-hypoxia drug and chrysin technology, applied in the field of medicine, can solve the problems of lack of anti-hypoxic injury protection drugs and no anti-hypoxia activity yet.

Active Publication Date: 2014-06-25
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the prevention effect or economic cost and other reasons, there is a shortage of anti-hypoxic injury protection drugs suitable for popularization and application.
However, there is no report on anti-hypoxic activity research

Method used

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  • Application of chrysin in preparing anti-hypoxic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] tablet:

[0071] Chrysin (purity greater than 95%, Shaanxi Ciyuan Biotechnology Co., Ltd.) 50.0g,

[0072] Starch (filler, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 130.0g,

[0073] Microcrystalline cellulose (MCC, disintegrant, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 10.0g,

[0074] Methylcellulose (binder, Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) 6.0g,

[0075] Magnesium stearate (lubricant, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 4.0g,

[0076] 200.0g total.

[0077] Prepared according to the conventional tablet method, and made 1000 tablets in total, each containing 50 mg of chrysin.

Embodiment 2

[0079] Capsules:

[0080] Chrysin (purity greater than 95%) 50.0g,

[0081] Starch (filler) 135.0g,

[0082] Methylcellulose (binder) 5.0g,

[0083] Magnesium stearate (lubricant) 10.0g,

[0084] 200.0g total.

[0085] Prepare according to the conventional method of capsules, and make 1000 capsules altogether, each capsule contains 50 mg of chrysin.

Embodiment 3

[0087] Dispersible tablets:

[0088] Chrysin (purity greater than 95%) 50.0g,

[0089] Microcrystalline Cellulose 130.0g,

[0090] Croscarmellose sodium (cCMC-Na, Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) 20.0g,

[0091] 200.0g total.

[0092] Prepared according to the conventional method for dispersible tablets, a total of 1000 tablets were made, each containing 50 mg of chrysin.

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Abstract

The invention discloses an application of chrysin in preparing an anti-hypoxic drug. The anti-hypoxic drug is a drug for preventing and treating hypoxic injury diseases which are high-altitude low-pressure oxygen deficit-caused acute high altitude diseases, cerebral ischemia hypoxic diseases or myocardial ischemia hypoxic diseases. The application has beneficial effects as follows: experiments prove that the chrysin has a remarkable anti-hypoxic effect, and effect tending to be better than that of acetazolamide; the anti-hypoxic drug prepared by applying the chrysin as an active ingredient can be used for preventing and treating hypoxic injuries or treating various hypoxic pathological states caused by oxygen content drop in external environment, also can be used for preventing or treating hypoxic pathological states of heart, brain, respiratory system, and the like as external normal oxygen cannot sufficiently get to a body due to diseases, and the like, and further can be used for preventing or treating the pathological state that relative oxygen supply is insufficient as oxygen consumption needed for activities of the body exceeds physiological mobilization ability.

Description

[0001] technical field [0002] The invention relates to the field of medicine, in particular to the application of chrysin in the preparation of anti-hypoxic drugs. Background technique [0003] The pathological process that causes changes in body metabolism, function, and morphological structure due to the reduction of tissue oxygen supply or the obstruction of oxygen utilization is called hypoxia. With the change of people's lifestyle and the accelerated pace of life, hypoxia has become a fairly common pathological process. Oxygen supply and oxygen utilization disorders occur in circulatory and other system diseases. Third, the oxygen consumption required by the body is greater than the supply. Plateau hypoxia belongs to low-pressure hypoxia, which often makes people who first arrive at the plateau prone to acute altitude sickness such as headache, palpitations, chest tightness, shortness of breath, fatigue, sleep disturbance, nausea, and vomiting. Fatal diseases such a...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P39/00
Inventor 马慧萍景临林樊鹏程高荣敏蒋炜贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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