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Aminophylline tablet and preparation method thereof

A technology for aminophylline and alkali tablets, which is applied in the field of aminophylline tablets and its preparation, and can solve the problems of internal quality differences, unstable processes, and large differences in real-time dissolution behaviors, etc.

Inactive Publication Date: 2014-06-25
HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The most commonly used is aminophylline tablets, because of its convenient use and low price, it is very popular among patients. However, the existing aminophylline tablets have a problem of burst release. Some people have investigated the in vitro real-time dissolution curves of aminophylline tablets produced by different manufacturers. Comparing the differences between the manufacturers and the dissolution curves of aminophylline tablets in the Japanese Orange Book, it was found that the dissolution of aminophylline tablets in 31 companies was greater than 40% in 5 minutes, and all of them produced burst release. ; The real-time dissolution behavior of aminophylline tablets of some manufacturers in the four kinds of dissolution media is quite different, and there is a big difference in internal quality, and the homogeneity of aminophylline tablets produced by some manufacturers is poor, the process is unstable, and the product uneven quality

Method used

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  • Aminophylline tablet and preparation method thereof
  • Aminophylline tablet and preparation method thereof
  • Aminophylline tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] A kind of aminophylline tablet, comprises following component by weight percentage:

[0045]

[0046]

[0047] A preparation method of aminophylline tablet, comprising the following steps (the amount of each component is as described in Table 1):

[0048] (1) The aminophylline in the weight ratio is crushed and passed through a 65-mesh sieve.

[0049] (2) Take the microcrystalline cellulose, hypromellose and silicon dioxide in the weight ratio and the aminophylline powder, pass through a 65-mesh sieve and mix evenly.

[0050] (3) Add the magnesium stearate in the weight ratio and mix evenly.

[0051] (4) Press the mixed powder on the tablet machine to compress the tablet, and pack the finished product after the tablet is tested and qualified.

Embodiment 2

[0053] A kind of aminophylline tablet, comprises following component by weight percentage:

[0054] components weight Aminophylline 100 g microcrystalline cellulose 100 g hypromellose 1 silica 4 grams Magnesium stearate 2.04 grams

[0055] A preparation method of aminophylline tablet, comprising the following steps (the amount of each component is as described in Table 2):

[0056] (1) The aminophylline in the weight ratio is crushed and passed through a 65-mesh sieve.

[0057] (2) Take the microcrystalline cellulose, hypromellose and silicon dioxide in the weight ratio and the aminophylline powder, pass through a 65-mesh sieve and mix evenly.

[0058] (3) Add the magnesium stearate in the weight ratio and mix evenly.

[0059] (4) Press the mixed powder on the tablet machine to compress the tablet, and pack the finished product after the tablet is tested and qualified.

Embodiment 3

[0061] A kind of aminophylline tablet, comprises following component by weight percentage:

[0062] components weight Aminophylline 100 g microcrystalline cellulose 2 grams hypromellose 4 grams silica 2 grams Magnesium stearate 1 g

[0063] A preparation method of aminophylline tablet, comprising the following steps:

[0064] (1) The aminophylline in the weight ratio is crushed and passed through a 65-mesh sieve.

[0065] (2) Take the microcrystalline cellulose, hypromellose and silicon dioxide in the weight ratio and the aminophylline powder, pass through a 65-mesh sieve and mix evenly.

[0066] (3) Add the magnesium stearate in the weight ratio and mix evenly.

[0067] (4) Press the mixed powder on the tablet machine to compress the tablet, and pack the finished product after the tablet is tested and qualified.

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Abstract

The invention relates to an aminophyline tablet and a preparation method thereof. The aminophyline is prepared from the following components in parts by weight: 100 parts of aminophyline, 2-100 parts of microcrystalline cellulose, 1-4 parts of hydroxypropyl methylcellulose, 1-5 parts of silicon dioxide and 1-2 parts of magnesium stearate.

Description

Technical field: [0001] The invention relates to the preparation of a pharmaceutical preparation, in particular to an aminophylline tablet and its preparation. Background technique: [0002] Aminophylline is a double salt of theophylline and ethylenediamine. Its pharmacological effects mainly come from theophylline, and ethylenediamine enhances its water solubility. Aminophylline has a direct relaxing effect on airway smooth muscle. Its mechanism of action is relatively complicated. In the past, it was believed that the increase of intracellular cAMP content was caused by inhibiting phosphodiesterase. Recent experiments suggest that the bronchodilator effect of theophylline is partly due to the release of endogenous adrenaline and norepinephrine. In addition, theophylline is a purine receptor blocker that can resist the constriction of adenine and other airways. Theophylline can enhance the contractility of the diaphragm, especially when the contraction of the diaphragm is...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/522A61K47/38A61P11/08A61P9/08A61P7/10
Inventor 朱彦民孟祥宇刘妍
Owner HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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