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A kind of preparation method and application of low molecular altar laver polysaccharide-iron complex

A technology of laver and low molecular weight is applied in the treatment and prevention of iron-deficiency anemia, in the field of preparation of polysaccharide iron complexes, and can solve the problems of low absorption rate and the like, and achieves simple operation, low manufacturing cost and stable preparation process. Effect

Active Publication Date: 2016-08-17
HUZHOU TEACHERS COLLEGE
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Problems solved by technology

However, the absorption rate of oral high molecular weight polysaccharides is very low, so whether high molecular weight polysaccharide iron can also be directly absorbed in molecular form like low molecular weight iron preparations, and what is the optimal molecular weight range that can be absorbed needs to be further explored

Method used

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  • A kind of preparation method and application of low molecular altar laver polysaccharide-iron complex
  • A kind of preparation method and application of low molecular altar laver polysaccharide-iron complex
  • A kind of preparation method and application of low molecular altar laver polysaccharide-iron complex

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Embodiment Construction

[0022] 1. Preparation of Porphyra haitanensis polysaccharide

[0023] Weigh 100 g of dried Porphyra haitanensis, crushed, put it into a high-pressure extractor, add 40 times distilled water and extract for 3 hours at 105 °C. The extract was filtered with gauze to remove the algae residue, and then filtered with diatomaceous earth to obtain a clear extract. The extract was packed in a dialysis bag with a molecular weight cutoff of 3500 Da, dialysis with running tap water for two days, distilled water for one day, and then concentrated under reduced pressure. The concentrate was added with absolute ethanol to make the final concentration of ethanol reach 75%, and flocculent white precipitate was obtained. The precipitate was washed with absolute ethanol and dried to obtain 42 g of raw material polysaccharide of Porphyra haitanensis.

[0024] 2. Preparation of low molecular weight Porphyra haitanensis polysaccharide

[0025] Dissolve 4 g of the raw material polysaccharide of Porphyra ...

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Abstract

The invention provides a preparation method and application of a low-molecular porphyra haitanensis polyferose compound. The method is characterized in that low-molecular porphyran is used as a raw material and degraded by redox reaction to obtain low-molecular-weight porphyran with the molecular weight being less than 10000Da; and the polyferose compound synthesized by heating the porphyran and ferric chloride together can be dissolved well and exist stably under a physiological pH condition, and also shows a good effect in the iron-deficiency anemia mouse model experiment. The preparation method has the advantages of being simple and convenient in operation, stable in preparation process, low in preparation cost, etc.; and the preparation method also shows wide applicability to raw materials, namely, any polysaccharide with a proper molecular weight range is applicable to the preparation method.

Description

Technical field [0001] The invention belongs to the field of marine medical health products, and specifically relates to a preparation method of a polysaccharide iron complex using low-molecular Porphyra haitanensis polysaccharide as a raw material, and its application in the treatment and prevention of iron deficiency anemia. Background technique [0002] Iron deficiency anemia (DA) is one of the four most serious nutritional diseases in the contemporary world, which seriously affects human health. According to statistics published by the World Health Organization in 2002, 2 billion people worldwide suffer from iron deficiency, and iron deficiency is the ninth largest risk factor affecting human health. According to statistics, the current incidence of iron-deficiency anemia in my country is as high as 15%-20%. About 200 million people in the country suffer from iron-deficiency anemia and iron malnutrition, among which women and children are high-risk groups. [0003] Iron-defici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A23L29/00A23L33/125A61K31/715A61P7/06
Inventor 张忠山王晓梅
Owner HUZHOU TEACHERS COLLEGE
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