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Pharmaceutical composition for treating cystitis

A technique for cystitis and bladder perfusion, applied in the field of cystitis treatment

Active Publication Date: 2016-04-27
北京亿灵医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few of these treatments produce sustained relief

Method used

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  • Pharmaceutical composition for treating cystitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 collagen perfusate

[0022] Collagen

[0023] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates, 95.0% of the labeled amount, so that the pH value is within the range of 7.2±0.1, filled with nitrogen, filled (50ml / bottle), melt-sealed, sterilized, sterilized at 115°C for 30 minutes, inspected by light, and bottled .

Embodiment 2

[0024] The preparation of embodiment 2 collagen perfusate

[0025] Collagen

[0026] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates is 105.0% of the labeled amount, so that the pH value is within the range of 7.2±0.1, filled with nitrogen, filled (50ml / bottle), melt-sealed, sterilized, sterilized at 115°C for 30 minutes, inspected by light, and bottled .

Embodiment 3

[0027] The preparation of embodiment 3 collagen perfusate

[0028] Collagen

[0029] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates, 104.1% of the labeled amount, so that the pH value is within the range of 7.2±0.1, nitrogen filling, filling (50ml / bottle), melting sealing, sterilization, sterilizing at 115°C for 30 minutes, light inspection, and bottling .

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Abstract

The invention relates to a medicine composition for treating urocystitis. The medicine composition is characterized by consisting of collagen and a water carrier. The collagen composition solution disclosed by the invention is given in a perfusion manner, therefore, the medicine directionally reaches the surface of the infected cavity (mucosa) of the urinary bladder or patients suffering urocystitis, especially interstitial cystitis, can be used for treating related urinary bladders and is applicable to patents whose lining of the urinary bladder or urethra or lining of the ureter is corroded.

Description

technical field [0001] The present invention relates to therapeutic agents and methods for treating cystitis, including interstitial cystitis and related bladder disorders. Background technique [0002] Interstitial cystitis (interstitial cystitis, IC), also known as bladder submucosal fibrosis or Hunner's ulcer, is a multifactorial syndrome characterized by bladder fibrosis, pain in the suprapubic area during the storage period, and urinary frequency, urgency, or nocturia increased symptoms. At present, the pathogenesis is still unclear, and the treatment is based on clinical experience and symptomatic treatment. At present, bladder infusion is mostly used to treat interstitial cystitis clinically, and the methods used are various with different effects. [0003] Sant and LaRock pointed out in Interstitial Cystitis, Vol.21 (1) that existing treatments include drug therapy, and intravesical use of dimethyl sulfoxide is the only FDA-approved therapy. However, a variety of o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K9/00A61P13/10A61P13/02A61K31/737A61K31/728
Inventor 关屹闫冬高晓峰
Owner 北京亿灵医药科技发展有限公司
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