Method and system for quantifying hepatic fat in humans

A technology of fat, liver, applied in the direction of measurement using MRI system, measurement using magnetic variables, application, etc.

Active Publication Date: 2014-06-11
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although the use of NMR devices to study external samples has been well documented in the petroleum logging industry, the

Method used

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  • Method and system for quantifying hepatic fat in humans
  • Method and system for quantifying hepatic fat in humans
  • Method and system for quantifying hepatic fat in humans

Examples

Experimental program
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Embodiment Construction

[0020] refer to figure 1 , the portable NMR probe 100 performs low-field time-domain nuclear magnetic resonance (TD-NMR) inside a target tissue (eg liver) of a patient 300 in a region defined as a sensitive region 301 . Static B is generated by two or more magnet pieces 102 and 103 of opposite polarity mounted in a biocompatible base or housing portion 0 magnetic field. this B 0 The magnetic field aligns the spin states of the hydrogen nuclei found within the sensitive region 301 . Suitable materials for the magnets include samarium cobalt, niobium, other rare earth magnets, electromagnets, and the like. However, other magnetic materials known to those skilled in the art are also envisioned. The biocompatible base portion is preferably positioned over the right lower lobe of the patient's liver. In one embodiment, the magnets are configured such that within 5 cm of the magnet pieces 102 and 103 the static magnetic field lines extend laterally with a uniformity of about 10...

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Abstract

A probe unit (100) including a magnet (102, 103) generates a static magnetic B0 field in an examination region and a RF coil (105). An input-output module (201) includes a transmitter (203) which controls the RF coil (105) to excite resonance and cause echoes (210) and a receiver (204) which demodulates and digitizes the echoes (210). A data processing module (206) includes at least one processor programmed to calculate a T2 relaxation distribution plot from a digitized echo (210) train, calculate a first area under the fat peak on the T2 distribution plot, calculate a second area under a water peak on the T2 distribution plot, and normalize the first and second area to determine a fat-to-water ratio.

Description

technical field [0001] This application relates to the monitoring of liver fat in a subject by nuclear magnetic resonance (NMR). Background technique [0002] Recent medical resonance imaging (MRI) studies have focused on quantifying the amount of liver fat in patients. Liver fat quantification can be used to detect nonalcoholic fatty liver disease (NAFLD) and monitor the effects of disease management. NAFLD occurs when an abnormal amount of fat remains in the liver because excessive alcohol use is not involved, a buildup known as steatosis. If patients are left untreated, they can degeneratively develop liver disease, including fibrosis, cirrhosis, and hepatocellular carcinoma. [0003] Currently, relevant clinical information for detection and monitoring of NAFLD has been provided by MRI and by generating fat fraction maps with the mDIXON method. Invasive biopsy procedures have also been used to detect NAFLD and monitor disposition. The main disadvantages associated wi...

Claims

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Application Information

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IPC IPC(8): A61B5/055G01R33/383G01R33/50G01R33/38G01R33/48
CPCA61B5/4244G01R33/3808G01R33/4828G01R33/383A61B5/4872A61B5/055G01R33/50
Inventor T·珀金斯
Owner KONINKLJIJKE PHILIPS NV
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