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Controllable crosslinked bionic tissue adhesive and applications thereof

A tissue adhesive and oxidant technology, used in surgical adhesives, applications, medical science, etc., can solve the problems of non-curing, insufficient strength, and unsatisfactory fixation effect of damaged tissue, and achieve firm bonding, increased strength, Good fixed effect

Inactive Publication Date: 2014-04-30
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it still has shortcomings: this type of bionic tissue adhesive is a viscous liquid, although its adhesion is high, it does not solidify during use, the strength is not enough, and the fixation effect on damaged tissue is not ideal ( Stewart RJ, Ransom TC, Hlady V. Natural underwater adhesives. Journal of Polymer Science. 2011; 49(11), 757-771)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A controllable cross-linked bionic tissue adhesive, its components and mass ratio are:

[0025] 75 parts of liquid polymer, 10 parts of reducing agent, 15 parts of polymer microspheres loaded with oxidant;

[0026] The liquid polymer in this example is prepared by the following method: graft dopamine hydrochloride and methacrylic anhydride in a molar ratio of 1:1 to generate a monomer compound, and then graft the monomer compound and ethyl methoxyacrylate in a ratio of 1:1 The molar ratio is obtained by copolymerization.

[0027] The reducing agent used in this example is sodium tetraborate (Na 2 B 4 o 7 ).

[0028] The oxidant in the polymer microspheres used in this example is sodium periodate (NaIO 4 ).

[0029] The oxidant-loaded polymer microspheres of this example are made of 12 parts by mass of gelatin wrapped with 3 parts by mass of oxidant by emulsification.

[0030] The use of the controllable cross-linked bionic tissue adhesive in this example is as fo...

Embodiment 2

[0032] A controllable cross-linked bionic tissue adhesive, its components and mass ratio are:

[0033] 85 parts of liquid polymer, 5 parts of reducing agent, 10 parts of polymer microspheres loaded with oxidant;

[0034] The liquid polymer in this example is prepared by the following method: graft dopamine hydrochloride and methacrylic anhydride in a molar ratio of 1:1 to generate a monomer compound, and then graft the monomer compound and ethyl methoxyacrylate in a ratio of 1:1 The molar ratio is obtained by copolymerization.

[0035] The reducing agent used in this example is sodium tetraborate (Na 2 B 4 o 7 ).

[0036] The oxidant in the polymer microspheres used in this example is sodium periodate (NaIO 4 ).

[0037] The polymer microspheres loaded with oxidant in this example are made by wrapping 1 part of oxidant with 9 parts by mass of chitin by emulsification.

[0038] The use of the controllable cross-linked bionic tissue adhesive in this example is as follows:...

Embodiment 3

[0040] A controllable cross-linked bionic tissue adhesive, its components and mass ratio are:

[0041] 90 parts of liquid polymer, 0.5 part of reducing agent, 9.5 parts of polymer microspheres loaded with oxidant;

[0042] The liquid polymer in this example is prepared by the following method: graft dopamine hydrochloride and methacrylic anhydride in a molar ratio of 1:1 to generate a monomer compound, and then graft the monomer compound and ethyl methoxyacrylate in a ratio of 1:1 The molar ratio is obtained by copolymerization.

[0043] The reducing agent used in this example is sodium tetraborate (Na 2 B 4 o 7 ).

[0044] The oxidant in the polymer microspheres used in this example is sodium periodate (NaIO 4 ).

[0045] The oxidant-loaded polymer microspheres of this example are made of 8 parts by mass of albumin coated with 1.5 parts by mass of oxidant by ultrasonic method.

[0046]The application of the controllable cross-linked bionic tissue adhesive in this examp...

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PUM

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Abstract

The invention discloses a controllable crosslinked bionic tissue adhesive and applications thereof. The adhesive comprises the following components in parts by mass: 75-90 parts of liquid polymer, 0.5-10 parts of reducer, and 9.5-15% of oxidizer-carrying high polymer microspheres. The liquid polymer is prepared by grafting dopamine hydrochloride and methacrylic anhydride at a molar ratio of 1:1 to obtain a monomeric compound, and copolymerizing the monomeric compound and methoxy ethyl acrylate at a molar ratio of 1:1. The bionic tissue adhesive disclosed by the invention has the advantages of high adhesive force in in-vivo liquid environment, good rheological property at initial stage, accurate location by syringe, and complete contact and firm adhesion with adhesive interface, and also has filling and sealing functions and good hemostatic effect. The bionic tissue adhesive is cured to be an elastic solid with enhanced strength after several hours, has good fixing effect to damaged tissue, has firm adhesion, and can better promote healing of damaged tissue.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a bionic tissue adhesive and its application. Background technique [0002] Human tissue has a certain self-repair ability, and can self-repair some soft and hard tissue wounds that are close to each other and relatively fixed in position. Therefore, in order to ensure tissue repair, it is first necessary to fix the damaged wound to keep the wound tissue close and relatively fixed. Traditionally, mechanical fixation methods are often used, such as using sutures or rivets to fix its position and promote wound recovery. However, the effect of traditional methods such as suturing and stapling to fix damaged tissues is not ideal, because the sutures and rivets used do not have more functions (such as tight sealing of the injured part, anti-inflammation, etc.) and analgesia, etc.). In addition, during surgery, wound suturing may cause bleeding or damage surrounding tissues, resul...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/00A61L24/08A61L24/10A61L24/04
Inventor 熊雄屈树新刘宗光冯波汪建新鲁雄翁杰
Owner SOUTHWEST JIAOTONG UNIV
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