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Application of SIRT1 inhibitor and sorafenib in preparing medicaments for treating liver cancer

A 1.SIRT1, a technology for the treatment of liver cancer, applied in the field of chemistry, can solve the problems of drug resistance, high morbidity and mortality, and difficulty in eradicating traditional therapy, and achieve the effect of reducing drug resistance and eradicating tumors.

Active Publication Date: 2014-04-30
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology

[0002] Liver cancer is the fifth most malignant tumor in the world. It is mainly distributed in Asian and Southeast Asian countries. The morbidity and mortality remain high. Traditional therapies such as surgery, radiotherapy, and chemotherapy are difficult to eradicate completely. There is a lack of effective drugs for the treatment of liver cancer. The reason is that drugs are prone to intrinsic drug resistance

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  • Application of SIRT1 inhibitor and sorafenib in preparing medicaments for treating liver cancer
  • Application of SIRT1 inhibitor and sorafenib in preparing medicaments for treating liver cancer
  • Application of SIRT1 inhibitor and sorafenib in preparing medicaments for treating liver cancer

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[0020] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. For the experimental methods not specified in the examples, the conventional conditions are generally followed, such as the conditions described in the Molecular Cloning Experiment Guide (Third Edition, J. Sambrook et al.), or the conditions suggested by the manufacturer.

[0021] The liver cancer stem cell model liver cancer stem cell T1224 used in the present invention was constructed by our laboratory. This model contains a lentiviral expression vector (Nanog / GFP reporter system) constructed by the Nanog promoter regulating the GFP reporter gene. For the construction method, please refer to Shan et al.2012, hepatology , 56: 1014-1014; Lv-sh-Scramble plasmid and Lv-sh-SIRT1 plasmid were constructed by our laboratory, and the construction process is detailed in Shan et al.2012, Hepatology, 56: 1014-1014; HEK293 cells were preserved by our lab...

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Abstract

The invention belongs to the field of chemistry, particularly relates to an application of an SIRT1 inhibitor and sorafenib in preparing medicaments for treating liver cancer. The method of the invention can inhibit proliferation, differentiation and cloning of liver cancer stem cells, improve sensibility of liver cancer stem cells to sorafenib, reduce drug resistance of liver cancer stem cells to sorafenib, and enhance damage of sorafenib to liver cancer stem cells, so as to kill tumor stem cells from the source and bring new hope for eliminating tumors.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to the application of SIRT1 inhibitors combined with sorafenib in the preparation of drugs for treating liver cancer. Background technique [0002] Liver cancer is the fifth most malignant tumor in the world. It is mainly distributed in Asian and Southeast Asian countries. The morbidity and mortality remain high. Traditional therapies such as surgery, radiotherapy, and chemotherapy are difficult to eradicate completely. There is a lack of effective drugs for the treatment of liver cancer. The reason is that drugs are prone to inherent drug resistance. [0003] The pathogenesis of liver cancer is complex. The occurrence and development of cancer cells and the metastasis of cancer cells are closely related to various cell signal transduction pathways and growth factors in the cells. Among them, there are multiple cell signal transduction pathways Key genes or signaling molecules,...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/76A61K31/44A61P35/00A61K31/17A61K48/00
Inventor 钱程刘丽梅刘春刚沈俊杰单娟娟
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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