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Preparation method and apparatus of chitosan beads

A preparation device and chitosan technology, applied in the field of preparation of chitosan beads, can solve problems such as unstable process conditions and difficult high-efficiency production, and achieve the effects of good uniformity, simple method, and clean preparation process

Inactive Publication Date: 2014-04-23
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common preparation methods of chitosan beads or microspheres include titration method and reverse-phase suspension method, but the process conditions of these preparation methods are unstable at present, and it is difficult to produce continuously and efficiently

Method used

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  • Preparation method and apparatus of chitosan beads
  • Preparation method and apparatus of chitosan beads

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: It is a basic embodiment of the chitosan bead preparation method of the present invention. A kind of preparation method of chitosan beads, it is to use chitosan as raw material to prepare chitosan beads, comprising the steps:

[0034] A. Prepare chitosan solution and coagulation bath: dissolve chitosan in acetic acid solution to prepare chitosan solution; add sodium hydroxide to ethanol solution to dissolve, and prepare to promote chitosan to coagulate into beads coagulation bath;

[0035] B. Chitosan condenses into beads: inject the chitosan solution into the dropper, drop it into the coagulation bath through the dropper and stir; the dropper is a conductive hollow tube, and the dropper is transported with the chitosan solution The tube is also connected with a direct current power supply used to control the voltage between the dropper and the liquid level of the coagulation bath, and the particle size of the chitosan beads is adjusted by adjusting the vo...

Embodiment 2

[0038] Example 2: is a further example. Different from Example 1: the dropper is selected from medical needles; the residue on the washing chitosan beads is to wash the sodium hydroxide on the chitosan beads with deionized water; the chitosan beads after washing Store in PBS buffer at low temperature. The chitosan solution is injected into the dropper through a constant flow pump; the chitosan solution is dropped into the coagulation bath through the dropper and stirred by a magnetic stirrer. The concentration of the chitosan solution is 1.5% to 2.5% based on the mass of chitosan and the W / V percentage of the acetic acid solution volume, wherein the concentration of the acetic acid solution is 0.5% to 2% based on the W / V percentage of the mass of acetic acid and the volume of water The concentration of the coagulation bath liquid is 3.5% to 4.5% in terms of the mass of sodium hydroxide and the percentage of the volume of ethanol solution W / V, wherein the concentration of th...

Embodiment 3

[0039] Example 3: is a preferred embodiment. The difference from Embodiment 2 is that the adjustment range of the DC power supply voltage is 1000-6000 V.

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Abstract

The invention relates to a preparation method and apparatus of chitosan beads. Chitosan beads are prepared by using chitosan as a raw material. The preparation method comprises the steps: preparing a chitosan solution and a coagulation bath solution, coagulating chitosan into beads, washing the chitosan beads and storing the chitosan beads. The preparation apparatus is provided with a rack, wherein a chitosan bead forming container is arranged on a base, a dropper is arranged at the middle of the rack, a constant-flow pump, a direct current power supply and a chitosan solution bead stirrer are arranged on the rack, one electrode of the direct current power supply is connected with the dropper, and the other electrode of the direct current power supply is connected with a conductive ring in the coagulation bath solution, or is connected with the metal chitosan bead forming container. The preparation method has the advantages of stable process conditions, high efficiency, good quality of the chitosan beads, and is easy to operate and continuous in operation; the preparation method is clean in preparation process, and is a safe preparation method of the chitosan beads without generating toxic pollutants; the preparation apparatus of the chitosan beads is simple, small in occupation area, high in efficiency, low in energy consumption and capable of realizing industrialized scale production.

Description

Technical field [0001] The present invention involves the preparation method and its preparation device of the chitosan beads, and specially involves a method and device for continuous preparation of different particle size shell polysaccharides. Background technique [0002] Chitosan (Chitosan) is a kind of chitin deoxyl, and it is also a natural macromolecular compound. It is the second largest organic resource in the world after cellulose.The shell polysaccharide has good hydrophilicity, renewable and biocompatibility, and has no biological toxicity, safe and reliable.Under natural conditions, shell polysaccharides can be biodegradable and is a renewable biomass resource with abundant reserves. [0003] The basic unit of shell polycogen is glucose with amino -based, which is rich in amino and hydroxyl groups. These functional group response activity is stronger than chitin, and can be performed.Pymal group modification. [0004] The shells can be made into balls or microsphere...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L5/08
Inventor 李林白志强汤浪张震
Owner HUAZHONG AGRI UNIV
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