Narciprimine derivative salt

A narcissin and compound technology, which is applied to narcissin organic acid salt and its pharmaceutical application field, can solve the problems of adverse reactions, drug resistance, unsatisfactory therapeutic effect and the like, and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2014-03-26
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal.

Method used

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  • Narciprimine derivative salt
  • Narciprimine derivative salt
  • Narciprimine derivative salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Narcissus Ming Fumarate

[0048] The compound narcissus 2.71 g (0.01 mol) and fumaric acid 1.17 g (0.01 mol) were dissolved in 70 ml of boiling ethanol. The hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left for several hours in a temperature environment of 0-5°C to precipitate narcissin fumarate crystals, and then filter out narcissus luminal fumarate crystals, Washing with ethanol and drying under vacuum at 50°C yielded 3.87 g of product.

Embodiment 2

[0050] Narcissus Ming Fumarate

[0051] 2.68 g of the compound narcissus fumarate and 1.17 g of fumaric acid were stirred in 70 ml of refluxing ethanol until all the solids were dissolved. Activated carbon was added, the hot solution was filtered through diatomaceous earth, and the temperature was cooled to room temperature while stirring. After standing for several hours in a temperature environment of 0-5°C, narcissin fumarate crystals were precipitated, and the narcissin fumarate crystals were filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 3.85 g of product.

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Abstract

The invention relates to narciprimine and fumarate of narciprimine derivative or pharmaceutically acceptable solvan as well as application in preparing medicaments for treating cancers.

Description

Field of Invention [0001] The present invention relates to the field of medicinal chemistry, in particular, the present invention relates to a narcissin organic acid salt and its pharmaceutical application. Background technique [0002] At present, although there are many kinds of drugs for the treatment of cancer, these existing drugs are prone to cause multiple and severe adverse reactions, and some of them develop drug resistance, and the therapeutic effects of the existing drugs are still not ideal. The Chinese Patent Application for Invention Publication No. CN 101138564A describes some active compounds that have the ability to treat cancer. SUMMARY OF THE INVENTION [0003] The present invention discloses certain new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds, and pharmaceutical applications of these compounds and compositions. [0004] These compounds show good water solubility and solid form stability....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/056C07C51/41C07C57/15A61K31/4741A61P35/00
CPCC07D491/056
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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