Application of carmustin in preparation of medicine for treating lymjphoma

A technology for carmustine and lymphoma, applied in the direction of drug combination, antineoplastic drugs, amide active ingredients, etc., can solve the problems of large side effects, cancer patients cannot withstand surgery, etc., achieve broad market prospects, and prevent cancer recurrence Effect

Inactive Publication Date: 2014-03-05
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the more effective way is surgical resection, however, many cancer patients cannot afford surgery
In addition, radiation therapy and chemotherapy are also common methods of treating cancer, however, their side effects are very large, often killing cancer cells and killing patients

Method used

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  • Application of carmustin in preparation of medicine for treating lymjphoma
  • Application of carmustin in preparation of medicine for treating lymjphoma
  • Application of carmustin in preparation of medicine for treating lymjphoma

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preparation example Construction

[0012] The preparation method of carmustine involved in the present invention refers to the literature (Park, J.H.et al., 2012.Characterization of hydrophobic anti-cancer drug-loaded amphiphilic peptides as a gene carrier.Journal of Cellular Biochemistry, 113(5): 1645-1653. and Domb AJ, et al., 1999. Preparation and characterization of carmustine loaded polyanhydride wafers for treating brain tumors. Pharmaceutical Research, 16(5):762-765.)

[0013] The principles and features of the present invention are described below, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

Embodiment 1

[0014] Embodiment 1 The preparation of the compound carmustine tablet involved in the present invention:

[0015] Get 7.7 grams of compound carmustine, add 192.3 grams of conventional adjuvants for preparing tablets, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0016] Embodiment 2: the preparation of compound carmustine suspension involved in the present invention:

[0017] Take 400 mg of the compound carmustine, dissolve it in 100 microliters of ethanol, then add 100 milliliters of normal saline, add the conventional suspending agent, wetting agent, flocculant and deflocculant used to prepare the suspension, and mix well ,spare.

[0018] The following pharmacodynamic experiments will further illustrate its drug activity.

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Abstract

The invention relates to an application of carmustin in preparation of medicine for treating lymjphoma. The animal experiments show that carmustin can kill large solid tumor in animal body, but also can induce the antineoplastic of the body for immunization. Carmustin can prevent cancer recurrence of cancer patient, which can not be achieved by other anticancer medicines. Research and development of carmustin have wide market prospect, and the carmustin can be effectively used for a lot of treatments of lymph cancer patients.

Description

technical field [0001] The invention relates to the application of carmustine in the preparation of medicaments for treating lymphoma, and belongs to the new application field of carmustine. Background technique [0002] Environmental pollution and genetic factors can cause mutations in DNA and genes. Cancer cells originate from the uncontrolled growth of cells in the human body due to DNA mutations and damage. Usually, cancer cells grow to form a tumor, and the cancer cells will migrate to other places to continue to grow, thereby destroying normal tissues and organs, resulting in the death of the patient. According to statistics, cancer is currently the second leading cause of human death after cardiovascular disease, and about half of men and more than one third of women will develop cancer. At present, there is no effective way to deal with cancer, especially the treatment of advanced cancer patients. At present, the more effective way is surgical resection, but many c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/17A61P35/00
Inventor 周菊华
Owner LUDONG UNIVERSITY
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