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Traditional Chinese medicine drug for treating allergy and preparation method thereof

A technology of traditional Chinese medicine and pharmaceuticals, which is applied in the field of traditional Chinese medicine preparations and preparations for the treatment of allergies, and can solve problems such as short action time, unacceptable patient acceptance, and easy drug resistance

Inactive Publication Date: 2014-02-19
浙江省中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still great defects in the treatment, often the action time is short, and it is easy to relapse after drug withdrawal, especially can cause side effects such as central inhibition, anticholinergic effect and even cardiotoxicity, such as commonly used chlorpheniramine, diphenhydramine, etc. , phenergan, cyproheptadine, etc. After use, they often have side effects such as drowsiness, dry mouth, and dizziness. Patients are not willing to accept them. Those who work at high altitudes and high speeds cannot use them during work, and they are prone to drug resistance during long-term use.

Method used

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  • Traditional Chinese medicine drug for treating allergy and preparation method thereof
  • Traditional Chinese medicine drug for treating allergy and preparation method thereof
  • Traditional Chinese medicine drug for treating allergy and preparation method thereof

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preparation example Construction

[0069] The preparation method of this Chinese medicine preparation comprises the following steps:

[0070] (1) Weigh the dried buds of winter flowers, crush them into coarse powder, and pass through a 20-40 mesh sieve.

[0071] (2) Put the coltsfoot flower powder in an extractor, add 5 times the amount of ethanol with a concentration of 80%, reflux extraction twice, each time for 2 hours, filter while it is hot, combine the filtrates, recover the ethanol, and obtain the extract. After the extract is dispersed by adding 3 to 5 times the amount of water, it is extracted with ethyl acetate until it is colorless, the extracts are combined, and the ethyl acetate is recovered. The ethyl acetate extract was obtained with a yield of 2.31%.

[0072] (3) Put the coltsfoot flower powder in a supercritical extraction kettle for extraction, the process conditions are: the temperature of the extraction kettle is 45°C, the temperature of the separation kettle is 30°C, and the flow rate of C...

Embodiment 1

[0098] (1) Solvent extraction of coltsfoot flower

[0099] 50 kg of dried flower buds of Coltsfoot, crushed, added 5 times the amount of 80% ethanol, refluxed twice for 2 hours each time, filtered while hot, combined filtrates, recovered ethanol, and obtained extract. Add 3-5 times the amount of water to the extract to disperse, extract with ethyl acetate until colorless, combine the extracts, recover ethyl acetate, and obtain ethyl acetate extract (Kdr), with a yield of 2.31%.

[0100] (2) Silica gel column chromatography separation of Kdr

[0101] Weigh 1000g of Kdr, dissolve it in the same amount of methanol, add the same amount of silica gel (100-200 mesh), mix the sample, recover methanol under reduced pressure, put it on the column, perform silica gel column chromatography separation, and use petroleum ether / ethyl acetate in turn (70:1, 60:1, 35:1, 15:1, 10:1, 4:1) and methanol elution, TLC detection, combined fractions of the same spot to obtain 7 fractions (Kdr1~Kdr7)...

Embodiment 2

[0106] (1) Supercritical extraction of coltsfoot flower

[0107] 50kg of dried buds of coltsfoot flower are crushed, placed in a supercritical extraction kettle, and the CO2 is cooled and then pressurized to a predetermined pressure for extraction. The temperature of the extraction kettle is 45°C, the temperature of the separation kettle is 30°C, and the CO 2 Flow rate 45kg·h -1 , pressure 25MPa, extraction time 2hr, the supercritical extract Kdj1000g was obtained, and the yield was 1.32%.

[0108] (2) Silica gel column chromatography separation of Kdj

[0109] Weigh the extracted winter flower extract Kdj 1000g, dissolve it in the same amount of methanol, add the same amount of silica gel, mix the sample, recover the methanol under reduced pressure, put it on the column, carry out silica gel column chromatography separation, and use petroleum ether / ethyl acetate (70 : 1-60: 1-35: 1-15: 1) and methanol elution, TLC detection, combined the fractions of the same spots to obtai...

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Abstract

The invention discloses a traditional Chinese medicine drug for treating allergy and a preparation method thereof. The preparation comprises the effective parts of tussilagone and derivates thereof, which are obtained by performing chromatographic separation pm a supercritical extract or an ethanol extract of flos farfarae via a silicagel column, wherein the mass ratio of the tussilagone to the derivates is (60-95):(5-40). The traditional Chinese medicine drug disclosed by the invention has a significant treatment effect on an allergic disease, is free of central inhibition effects such as drowsiness, thirst, dizziness and the like, and has the advantages that the western medicine does not have.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and natural medicine, in particular to a traditional Chinese medicine preparation for treating allergies and a preparation method thereof. Background technique [0002] Allergic reactions, also known as allergies, are tissue damage or physiological dysfunction caused by the stimulation of antigenic substances, and are abnormal and pathological immune reactions. Allergic rhinitis, asthma, itching, etc. are relatively common allergies. With the continuous deterioration of the global ecological environment, the occurrence of allergic diseases continues to increase. Domestic epidemiological surveys show that the incidence of allergic diseases in my country is as high as 37.5%. Allergic diseases have seriously affected human life and life, become a major global public health problem, and are listed by the World Health Organization (WHO) as one of the three major diseases that should be stu...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K31/22A61P37/08A61K133/00
Inventor 杨苏蓓张如松王溶溶毛培江杨毅陈雪园
Owner 浙江省中药研究所有限公司
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