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Preparation method and application of toothache anti-inflammation tablets

A technology of Xiaotong Xiaoyan Tablets and Toothache, which is applied in the field of preparation of Toothache Xiaoyan Tablets, to achieve the effects of small dosage, reduced dosage, and no bitterness in the dosage

Inactive Publication Date: 2014-02-12
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on toothache anti-inflammatory granules using supercritical and microwave technology in the extraction and preparation, while volatile oil extraction, dipping and percolation, decoction The method is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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  • Preparation method and application of toothache anti-inflammation tablets

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Effect test

Embodiment 1

[0032] Take gypsum 200g, Nepeta 80g, Fangfeng 80g, Qingpi 100g, Moutan cortex 100g, Dihuang 150g, Qingdai 100g, Asarum 60g, Angelica dahurica 50g, Licorice 60g, add Nepeta, Asarum, Angelica dahurica, Qingdai to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. , 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced p...

Embodiment 2

[0035] Take gypsum 200g, Nepeta 80g, Fangfeng 80g, Qingpi 100g, Moutan cortex 100g, Dihuang 150g, Qingdai 100g, Asarum 60g, Angelica dahurica 50g, Licorice 60g, add Nepeta, Asarum, Angelica dahurica, Qingdai to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. , 5 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduc...

Embodiment 3

[0038] Take gypsum 200g, Nepeta 80g, Fangfeng 80g, Qingpi 100g, Moutan cortex 100g, Dihuang 150g, Qingdai 100g, Asarum 60g, Angelica dahurica 50g, Licorice 60g, add Nepeta, Asarum, Angelica dahurica, Qingdai to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. , 10 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduc...

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Abstract

The invention belongs to the technical field of traditional Chinese medicaments, and in particular relates to a preparation method and application of toothache anti-inflammation tablets. The toothache anti-inflammation tablets are prepared from the following raw materials: 200g of gypsum, 80g of herba schizonepetae, 80g of divaricate saposhnikovia root, 100g of pericarpium citri reticulatae viride, 100g of paeonia suffruticosa, 150g of rehmannia, 100g of indigo naturalis, 60g of asarum, 50g of angelica root and 60g of liquorice by adopting supercritical extraction and microwave extraction, so that the content of hesperidin is greatly increased. The invention also provides application of the toothache anti-inflammation tablets in preparation of medicaments for inhibiting L1210 cell multiplication of leukemia cells of mice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method and application of Toothache Anti-inflammatory Tablets. Background technique [0002] Tooth pain anti-inflammatory granules are recorded on page 85 of the tenth volume of traditional Chinese medicine preparations and page 807 of the first part of the Chinese Pharmacopoeia 2010 edition. Asarum 60g, Angelica dahurica 50g, and licorice 60g are made as raw materials, which have the effects of dispelling wind and clearing heat, cooling blood and relieving pain. It is used for headache, body heat, dry mouth and bad breath, constipation, gingival swelling and pain caused by accumulated heat in the spleen and stomach, wind-heat attack; acute apical periodontitis, wisdom tooth pericoronitis, acute gingival (periodial) inflammation, acute dental Myelitis see the above syndrome. [0003] In the prior art, there is no report on tootha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/20A61P35/02A61K33/06
Inventor 岳蔷薇
Owner SHANDONG PROVINCIAL HOSPITAL
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