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Rapidly-dispersed water-mixed suspension medicine used for eyes

A technology of suspension and eye water, applied in the field of ophthalmic drugs, can solve the problems of drug concentration inconsistent with the nominal value, poor redispersibility, etc., and achieve the effect of good adaptability and good redispersibility

Inactive Publication Date: 2014-02-12
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problem that the concentration of the drug dropped into the eye does not match the nominal value due to the poor redispersibility of the existing ophthalmic suspension
Generally, laser particle size analyzer is used for detection

Method used

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  • Rapidly-dispersed water-mixed suspension medicine used for eyes
  • Rapidly-dispersed water-mixed suspension medicine used for eyes
  • Rapidly-dispersed water-mixed suspension medicine used for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 Eccarteprednol ophthalmic suspension

[0063] Eccaroteprednol 5g

Embodiment 2

[0064] Embodiment 2 fluorometholone eye water suspension

[0065] Fluorometholone 1g Sodium Hyaluronate 1g

Embodiment 3

[0066] Embodiment 3 Eccloteprednol tobramycin

[0067] Eccaroteprednol 3g

[0068] Tobramycin 5g, after adding tobramycin to solution during preparation, adjust the pH to 5-6 with sulfuric acid.

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Abstract

The invention discloses a rapidly-dispersed water-mixed suspension medicine used for eyes. The water-mixed suspension medicine comprises one or more water insoluble medicines, water, and one or more auxiliary materials suitable for water-mixed suspension used for eyes. The water-mixed suspension medicine is characterized in that particle size distribution of micro powder of the water insoluble medicines simultaneously satisfies following conditions: the D50 is 3.1-3.7 [mu]m, the maximum diameter is less than 30 [mu]m, the particle percentage of the micro powder having a diameter less than 1 [mu]m is 5%-9%, the particle percentage of the micro powder having a diameter of 1-10 [mu]m is 86%-91%, and the particle percentage of the micro powder having a diameter not more than 10 [mu]m is 93%-98%.

Description

Technical field: [0001] The invention relates to an ophthalmic drug, which is an aqueous suspension drug prepared from insoluble drug micropowder. Background technique: [0002] Aqueous suspension is an important form of preparing ophthalmic preparations from water-insoluble drugs. Suspensions are thermodynamically unstable systems, and particles tend to aggregate to minimize their surface free energy. Due to the large specific surface area of ​​the particles, the chances of the particles colliding with each other increase. At the same time, there is a strong mutual attraction between the particles and a strong intermolecular force. The particles are prone to irreversible aggregation to reduce their surface energy (Wong J, Brugger A , Khare A, et al.Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects [J]. Adv Drug Deliv Rev, 2008, 60(8): 939-954; Kesisoglou F, Panmai S, Wu Y.Nanosizing--oral formulation development and bioph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K45/00A61P27/02
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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