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Anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression and preparation method of anti-hair loss Chinese herbal medicine compound

A technology of androgen receptor and Chinese herbal medicine, which is applied in the field of pharmaceutical compositions for preventing hair loss, can solve the problems of large side effects, blindness of treatment, and large irritation of western medicine components, and achieve low production cost, convenient application, and increase scalp blood microbes. loop effect

Active Publication Date: 2013-12-11
GUANGZHOU TIANWEN JIAOYAN COSMETICS
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Problems solved by technology

However, the ingredients of western medicine are highly irritating and have large side effects, so the treatment has a certain degree of blindness and potential danger.

Method used

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  • Anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression and preparation method of anti-hair loss Chinese herbal medicine compound
  • Anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression and preparation method of anti-hair loss Chinese herbal medicine compound
  • Anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression and preparation method of anti-hair loss Chinese herbal medicine compound

Examples

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Embodiment 20

[0046] The preparation steps of each Chinese herbal medicine extract in Example 20 and Example 21 include: pulverizing the corresponding Chinese herbal medicine, soaking the pulverized Chinese herbal medicine in 70% (mass percentage) ethanol under negative pressure for 7 days, and the soaking extraction temperature is 20 °C; filter the mixed solution obtained after soaking, and concentrate the obtained filtrate at 40 °C to obtain the corresponding Chinese herbal medicine extract.

[0047] The preparation steps of each Chinese herbal medicine extract in Example 22, Example 23 and Example 24 are as follows: pulverize the corresponding Chinese herbal medicine, soak the pulverized Chinese herbal medicine in pure water under normal pressure for 15 days, and the soaking extraction temperature is 35°C; The mixed solution obtained after soaking is filtered, and the obtained filtrate is concentrated at 60° C. to obtain the corresponding Chinese herbal medicine extract.

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Abstract

The invention discloses an anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression, belonging to pharmaceutical compositions. The anti-hair loss Chinese herbal medicine compound contains an astragalus extract, a dodder extract, a scutellaria baicalensis extract, a pueraria extract, a rhizoma chuanxiong extract, a malaytea scurfpea fruit extract, a rhizoma coptidis extract and a shrubby sophora extract, wherein the weight percentage of each Chinese herbal medicine extract accounting for the total weight of the anti-hair loss Chinese herbal medicine compound is 0.1%-99%. The anti-hair loss Chinese herbal medicine compound with antagonism androgen receptor expression disclosed by the invention is used for treating seborrheic alopecia caused by male androgen source character.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing hair loss, in particular to a Chinese herbal medicine compound for preventing hair loss and antagonizing the expression of androgen receptor; the invention also relates to a preparation method of the Chinese herbal medicine compound for preventing hair loss. Background technique [0002] Androgen ical alopecia (AGA), also known as male pattern alopecia (MPA), is a common and frequently-occurring disease in dermatology, and its etiology is complex. Although the patient had no obvious symptoms, he urgently required treatment because of the impact on the appearance. Studies in recent years have shown that the androgen receptor (AR) in the follicular unit plays an important role in the pathogenesis of AGA. Decreased AR expression or / and androgen affinity in hair follicles of alopecia patients is one of the important ways to antagonize androgen-induced hair follicles leading to AGA. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K8/97A61P17/14A61Q7/00
Inventor 吴培诚欧春凤梁高卫邹宏图刘伟成姚中华周磊
Owner GUANGZHOU TIANWEN JIAOYAN COSMETICS
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