Microfluidic chip for producing multicomponent droplets

A microfluidic chip and microdroplet technology, applied in the field of microfluidics

Inactive Publication Date: 2013-11-13
苏州扬清芯片科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing droplet technology is still difficult to simultaneously generate a large number of micro-droplets with different components.

Method used

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  • Microfluidic chip for producing multicomponent droplets
  • Microfluidic chip for producing multicomponent droplets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0016] Embodiment A kind of microfluidic chip for producing concentration gradient microdroplets

[0017] In order to realize mass production of micro-droplets with different components, the present invention proposes a microfluidic chip for producing concentration-gradient micro-droplets, which is prepared from PDMS. Such as figure 1 As shown, the microfluidic chip is composed of three parts, which are droplet production unit 1, product introduction hole 2 and sample mixing and reaction unit 3. Among them, the droplet generation unit 1 is mainly composed of the oil phase inlet and channel, and the droplet outlet; the sample mixing and reaction unit 3 is composed of different sample inlets, and two channels for mixing and mixing; between 1 and 3, the product The introduction hole 2 is connected.

[0018] When the above-mentioned microfluidic chip is used for droplet preparation, different sample solutions A, B, and C are passed into the sample holes in the sample mixing and ...

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PUM

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Abstract

The invention provides a microfluidic chip for producing droplets with concentration gradients. The microfluidic chip is characterized by comprising a sample solution inlet and channel, a concentration gradient generating unit, a water phase import hole, an oil phase inlet and channel, a droplet generating unit and a droplet outlet, wherein the droplets with concentration gradients are formed by injecting products which are exported from the concentration gradient generating unit and have concentration gradients into a flowing oil phase in the droplet generating unit, thus continuously obtaining water-in-oil droplets with corresponding concentrations. By using the microfluidic chip provided by the invention, plenty of droplets of inclusions with concentration gradients can be generated on line in real time and are expected to be applied to the fields such as drug screening, chemical synthesis, material preparation, chemical production and the like.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic chip for producing multi-component microdroplets. Background technique [0002] Micro-droplet microfluidics (droplet-based microfluidics) is a technology platform developed on microfluidic chips in recent years to manipulate small-volume liquids. One of them is the continuous phase, and the other is the dispersed phase. After the continuous phase and the dispersed phase enter the microchannel at the same time, under the action of the microchannel, the dispersed phase is dispersed in a small volume (10 -15 ~10 -9 L) The form of the unit is distributed in the continuous phase to form a series of discrete micro-droplets, and each droplet is used as a micro-reactor to complete a set of chemical or biological reactions. The use of micro-droplets for screening has the following advantages: 1) The sample consumption is very small, which greatly reduces the screeni...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 叶嘉明
Owner 苏州扬清芯片科技有限公司
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