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Position-adjustable optical projection tomography system sample fixing device

A technology of optical projection tomography and fixing devices, which is applied in the preparation of test samples and the measurement of color/spectral characteristics, etc. It can solve the problems of the reduction of the magnification of microscopic devices and achieve the effect of fast fixing

Active Publication Date: 2013-10-23
INST OF AUTOMATION CHINESE ACAD OF SCI
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to prevent the sample from rotating out of the field of view of the detector, the magnification of the microscope can only be reduced, which will sacrifice the information of the sample

Method used

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  • Position-adjustable optical projection tomography system sample fixing device
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  • Position-adjustable optical projection tomography system sample fixing device

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Embodiment Construction

[0016] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with the accompanying drawings.

[0017] The optical signal collected by the optical projection tomography system is relatively weak, but in the excited state, the optical signal of the excitation light entering the detector due to reflection is relatively strong, and sometimes even exceeds the optical signal generated by the sample. Therefore, in order to reduce the reflected light of the system, all components in the system are sprayed with black light-absorbing materials.

[0018] figure 1 A schematic structural view of a position-adjustable sample fixing device proposed in an embodiment of the present invention is shown. Such as figure 1 As shown, the sample fixing device includes: a precision translation stage, a fixing guide, a chuck body, jaws, jaw driving and adhesion columns. The sampl...

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Abstract

The invention discloses a position-adjustable optical projection tomography system sample fixing device. According to the device, a sample is fixed with two methods which are adhesion fixing and clamp fixing. The device comprises a precise translation stage with which a sample position can be integrally adjusted on two vertical directions, a fixed guiding device cooperating with a clamping claw when holding and fixing a sample such that a glass capillary containing the sample is vertically fixed in a chuck body; a chuck body used for fixing the guiding device, the clamping claw and an adhesion column; a clamping claw used for synchronically locking the glass capillary containing the sample when the sample is held and fixed, such that the glass capillary is positioned at the center of the chuck body; a clamping claw drive used for synchronically locking the clamping claw when the sample is held and fixed; and an adhesion column. During adhesion fixing, one end of the adhesion column is adhered to the sample, and the other end is fixed on the center of the chuck body. The system provided by the invention has the advantages of reasonable structure, good functions, convenient operation, and low cost.

Description

technical field [0001] The invention belongs to the technical field of molecular imaging, in particular to a position-adjustable optical projection tomography system sample fixing device. Background technique [0002] Optical projection tomography (Optical Projection Tomography, OPT) technology can realize structural and molecular specific imaging of biological samples with a scale of 1-10 mm. In the OPT imaging process, the sample is relatively thin and relatively transparent, and the scattering effect is negligible when visible light passes through the sample, and the photon is mainly absorbed by the sample, so it can be considered that the light propagates through the sample along a straight line. During OPT scanning, the sample is fixed on a high-precision rotary table, and a highly stable LED or laser is used as the irradiation source. The optical signal is amplified by a microscopic device and then transmitted to a high-sensitivity electron multiplying CCD detector. F...

Claims

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Application Information

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IPC IPC(8): G01N1/36G01N21/31
Inventor 田捷郭进董迪杨鑫马喜波施亮亮
Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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