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Application of chronic-gastritis-treating traditional Chinese medicine in preparing medicine used for preventing gastric ulcer

A technology for chronic gastritis and gastric ulcer, applied in the field of medical preparations

Inactive Publication Date: 2013-10-23
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, neither the report that the pharmaceutical composition described in the above-mentioned patent application can treat gastric ulcer nor the description that the pharmaceutical composition described in the above-mentioned patent application can treat tissue damage beyond the muscularis mucosa

Method used

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  • Application of chronic-gastritis-treating traditional Chinese medicine in preparing medicine used for preventing gastric ulcer
  • Application of chronic-gastritis-treating traditional Chinese medicine in preparing medicine used for preventing gastric ulcer
  • Application of chronic-gastritis-treating traditional Chinese medicine in preparing medicine used for preventing gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Prescription: Sanchaku 75g, Jiulixiang 75g, Liangmianzhen 75g, Muxiang 45g, Scutellaria baicalensis 30g, Poria cocos 30g, Dihuang 30g, Baishao 30g.

[0029] 2. Preparation of active ingredients:

[0030] (1) Weigh the crude drug in proportion, first add 8 times the volume concentration of ethanol with a volume concentration of 95% for reflux extraction for 1.5 hours, and then use 50% volume concentration of ethanol for reflux extraction for 3 times, each time adding 8 times the volume concentration of Extract with 50% ethanol for 0.5h; then, combine the extracts, condense by rotary evaporation under reduced pressure at 60°C until there is no alcohol smell, and obtain the alcohol extract;

[0031] (2) According to the volume ratio of ethanol extract:macroporous adsorption resin of 1:1, the obtained ethanol extract is loaded on the AB-8 macroporous adsorption resin column with a diameter-to-height ratio of 1:6. After fully infiltrating and saturating for 30 minutes un...

Embodiment 2

[0037] 1. Prescription: Sanchaku 70g, Jiulixiang 80g, Liangmianzhen 70g, Muxiang 40g, Scutellaria baicalensis 35g, Poria cocos 35g, Dihuang 35g, Baishao 25g.

[0038] 2. Preparation of active ingredients:

[0039] (1) Weigh the crude drug in proportion, first add 8 times the volume concentration of ethanol with a volume concentration of 95% for reflux extraction for 1.5 hours, and then use 50% volume concentration of ethanol for reflux extraction for 3 times, each time adding 8 times the volume concentration of Extract with 50% ethanol for 0.5h; then, combine the extracts, condense by rotary evaporation under reduced pressure at 60°C until there is no alcohol smell, and obtain the alcohol extract;

[0040] (2) According to the alcohol extract: macroporous adsorption resin volume ratio of 1:1, the obtained alcohol extract is loaded on the D101 macroporous adsorption resin column with a diameter-to-height ratio of 1:6, and the adsorption flow rate is 1ml After fully infiltratin...

Embodiment 3

[0046] 1. Prescription: Sanchaku 80g, Jiulixiang 70g, Liangmianzhen 80g, Muxiang 50g, Scutellaria baicalensis 25g, Poria cocos 25g, Dihuang 25g, Baishao 35g.

[0047] 2. Preparation of active ingredients:

[0048] (1) Weigh the crude drug in proportion, first add 8 times the volume concentration of ethanol with a volume concentration of 95% for reflux extraction for 1.5 hours, and then use 50% volume concentration of ethanol for reflux extraction for 3 times, each time adding 8 times the volume concentration of Extract with 50% ethanol for 0.5h; then, combine the extracts, condense by rotary evaporation under reduced pressure at 60°C until there is no alcohol smell, and obtain the alcohol extract;

[0049] (2) According to the volume ratio of ethanol extract: macroporous adsorption resin of 1:1, the obtained ethanol extract is loaded on the X-5 macroporous adsorption resin column with a diameter-to-height ratio of 1:6. After fully infiltrating and saturating for 30 minutes un...

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Abstract

The invention relates to an application of a chronic-gastritis-treating traditional Chinese medicine in preparing a medicine used for preventing gastric ulcer. The effective component of the medicine is prepared with the raw materials of, by weight: 70-80 parts of evodia lepta, 70-80 parts of common jasminorange twig and leaf, 70-80 parts of shinyleaf pricklyash root, 40-50 parts of banksian rose, 25-35 parts of Baikal skullcap root, 25-35 parts of tuckahoe, 25-35 parts of rehmannia, and 25-35 parts of white peony root. The preparation method of the effective component comprises the steps that: the raw materials are subjected to double extraction respectively by using concentrated alcohol and dilute alcohol; and purification is carried out by using macroporous absorption resin, such that the medicine is obtained.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine preparation with an undetermined structure containing rehmannia plants. Background technique [0002] In recent years, due to people's accelerated pace of work, irregular diet, and excessive mental stress, the incidence of stomach problems has begun to increase year by year, the most common of which are mainly gastritis and gastric ulcer. [0003] Gastritis refers to the inflammatory changes of gastric mucosa caused by various etiologies, which can be divided into acute and chronic types. The common types of acute gastritis are simple and erosive. The former manifests as epigastric discomfort, pain, anorexia, nausea, and vomiting; the latter manifests as gastrointestinal bleeding, with hematemesis and melena. Chronic gastritis can usually be divided into superficial gastritis, atrophic gastritis and hypertrophic gastritis. The course of chronic gastritis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P1/04
Inventor 刘中秋蔡铮罗辉麦扬钟天恒李绪乾雷晓璐武飞臻
Owner SOUTHERN MEDICAL UNIVERSITY
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