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Application of Chukrasone A in preparing medicines for treating yellow fever virus infection

A technology of yellow fever virus and medicine, applied in the direction of antiviral agents, pharmaceutical formulas, and resistance to vector-borne diseases, etc., to achieve the effect of highlighting substantive characteristics, effective prevention and treatment, huge social benefits and research value

Inactive Publication Date: 2013-10-23
丁圣雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no cases reported in China, but this does not make us relax our vigilance against the virus, because China's climate and geographical environment are complex, and there are many types of mosquitoes, which have the conditions for transmission. At the same time, with the increasing frequency of international exchanges, YFV It is very likely that it will be introduced into China

Method used

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  • Application of Chukrasone A in preparing medicines for treating yellow fever virus infection
  • Application of Chukrasone A in preparing medicines for treating yellow fever virus infection
  • Application of Chukrasone A in preparing medicines for treating yellow fever virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of the compound Chukrasone A tablet involved in the present invention:

[0038] Take 20 grams of compound Chukrasone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0039] Embodiment 2: the preparation of the compound Chukrasone A capsule involved in the present invention:

[0040] Get 20 grams of compound Chukrasone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0041] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0043] A kind of application of Chukrasone A in the preparation treatment or prevention yellow fever virus infection medicine, its steps are:

[0044] Toxicity test of A. Chukrasone A on Vero cells

[0045] Vero cells (African green monkey kidney cells) are susceptible cells to YFV.

[0046] The experimental steps are as follows:

[0047] 1: Inoculate Vero cells: Use DMEM medium containing 10% (v / v) fetal bovine serum to make a single cell suspension, inoculate 1000-10000 cells per well into a 96-well cell culture plate, and inoculate a volume of 100ul per well ;

[0048] 2: Culture Vero cells: at 37°C, 5% (v / v) CO 2 Under culture conditions, cultivate for 2 days;

[0049] 3: Add Chukrasone A: Discard the DMEM medium in each well, add 100ul to each well and dilute to the corresponding concentration with DMEM medium containing 10% (v / v) fetal bovine serum (0uM, 0.4uM, 1.2 uM, 3.7uM, 11uM, 33uM, 100uM, 300uM) of Chukrasone A, add 100ul of DMEM medium containing 10% (v / v) fe...

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Abstract

The invention discloses an application of Chukrasone A in preparing medicines for treating or preventing yellow fever virus infection. The Chukrasone A can effectively inhibit proliferation of yellow fever virus but is small in cytotoxicity, so that the Chukrasone A can be further developed to medicines for treating diseases caused by the virus infection, and has a wide application prospect. The use of the Chukrasone A for preparing medicines for treating yellow fever virus infection provided by the invention is disclosed for the first time. As the framework type belongs to a brand-new framework type, and the inhibitory activity of the Chukrasone A to yellow fever virus infection is unimaginably strong, the probability of giving any enlightenment by other compounds does not exist. The Chukrasone A has remarkable substantial characteristics and meanwhile has remarkable progress for preventing and treating yellow fever virus infection.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to the application of Chukrasone A in the preparation of medicines for treating or preventing yellow fever virus infection. Background technique [0002] Yellow fever virus (YFV) is a member of the Flavivirus genus in the family Flaviviridae. Yellow fever virus causes yellow fever, an acute infectious disease. Yellow fever has been designated as a quarantine infectious disease internationally, and China has also designated it as a Class A infectious disease. In 1648, the YUCATAN peninsula in America first confirmed the prevalence of yellow fever. From the 17th to the 19th century, the disease was brought to Europe and North America through transportation. In almost two centuries, yellow fever became one of the most serious plagues in some parts of the United States, Africa, and Europe, causing a large number of deaths. Since the 20th century, the disease has not occurre...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61P31/14
CPCY02A50/30
Inventor 丁圣雨
Owner 丁圣雨
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