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Method for preparing collagen modified regenerated cellulose composite material

A technology of regenerated cellulose and regenerated cellulose film, applied in medical science, absorbent pads, prostheses, etc., can solve problems such as weak bonding and unstable performance of composite materials, and achieve rapid healing, moisturizing and moisture permeability Good effect of promoting proliferation and migration

Active Publication Date: 2015-04-29
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the collagen / cellulose composite is prepared by physical adsorption, the bond between collagen and cellulose molecules is not strong, and the properties of the composite are not stable.

Method used

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  • Method for preparing collagen modified regenerated cellulose composite material
  • Method for preparing collagen modified regenerated cellulose composite material
  • Method for preparing collagen modified regenerated cellulose composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] NaOH / urea / water (7wt% / 12wt% / 81wt%) solvent system was used to dissolve natural cellulose with a degree of polymerization of 500 to obtain a 4wt% cellulose solution, which was used to prepare a regenerated cellulose membrane. The regenerated cellulose membrane was washed several times with deionized water to remove residual inorganic salts and other impurities. Then soak the regenerated cellulose membrane in a sodium periodate aqueous solution with a concentration of 1wt%, adjust the pH to 1, and react at 15°C for 15 minutes. The water is washed repeatedly to obtain the regenerated cellulose membrane with C2 and C3 aldehydes. Then react the aldylated regenerated cellulose membrane with 0.05% collagen solution at 4°C for 30 minutes, take it out, wash off the residual collagen on the surface with deionized water, and freeze-dry to obtain the collagen-modified regenerated cellulose composite material . The properties of the prepared composite materials are shown in Table ...

Embodiment 2

[0059] The NaOH / urea / water (7wt% / 12wt% / 81wt%) solvent system was used, and the method was the same as in Example 1. The regenerated cellulose membrane was washed several times with deionized water to remove residual inorganic salts and other impurities. Then soak a certain amount of regenerated cellulose film in a sodium periodate aqueous solution with a concentration of 3wt%, adjust the pH to 2, and react at 20°C for 30 minutes. After the reaction is completed, soak in ethylene glycol to remove the residual sodium periodate, and then Repeated washing with deionized water to obtain the regenerated cellulose membrane with C2 and C3 aldehydes. Then react the aldylated regenerated cellulose membrane with 0.2% collagen solution at 10°C for 1 hour, take it out, wash off the remaining collagen on the surface with deionized water, and freeze-dry to obtain the collagen-modified regenerated cellulose composite material . The properties of the prepared composite materials are shown in...

Embodiment 3

[0061] The NaOH / urea / water (7wt% / 12wt% / 81wt%) solvent system was used, and the method was the same as in Example 1. The regenerated cellulose membrane was washed several times with deionized water to remove residual inorganic salts and other impurities. Then soak a certain amount of regenerated cellulose film in a sodium periodate aqueous solution with a concentration of 3wt%, adjust the pH to 3, and react at 25°C for 1 hour. After the reaction is completed, soak it in ethylene glycol to remove the residual sodium periodate, and then Repeated washing with deionized water to obtain the regenerated cellulose membrane with C2 and C3 aldehydes. Then react the aldylated regenerated cellulose membrane with 0.2% collagen solution at 15°C for 2 hours, take it out, wash off the remaining collagen on the surface with deionized water, and freeze-dry to obtain the collagen-modified regenerated cellulose composite material . The properties of the prepared composite materials are shown in...

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Abstract

The invention discloses a method for preparing a collagen modified regenerated cellulose composite material, which comprises the following steps of: after oxidizing hydroxyl on the surface of a regenerated cellulose membrane into formyl or carboxyl through different oxidation systems, reacting the regenerated cellulose membrane with collagen aqueous solution, and cleaning, freezing and drying to obtain the collagen modified regenerated cellulose composite material. The collagen modified regenerated cellulose composite material obtained in the invention overcomes the disadvantages of being poor in mechanical performance and degradation resistance, expensive in cost and the like in the pure collagen material; the composite material is capable of providing a good humid environment for wound repair, promoting proliferation and migration of cells, and accelerating rapid repair of wound; the method disclosed by the invention is simple and mature in process; the prepared composite material has good mechanical performance and biocompatibility and has wide application prospect in the fields, such as tissue repair, artificial skin, soft tissue matrix and the like.

Description

technical field [0001] The invention relates to a method for preparing collagen modified regenerated cellulose composite material. The prepared composite material can be applied in the fields of tissue wound repair material, tissue engineering skin scaffold material, soft tissue patch and the like. Background technique [0002] As a natural polymer biomaterial, collagen is a helical fibrous protein composed of three peptide chains, which has low immunogenicity, excellent biocompatibility and biodegradability, can guide tissue regeneration, promote It is an ideal scaffold material for tissue engineering because of its cell proliferation growth and hemostatic effect. Tissue repair is one of the important applications of collagen materials in the medical field. The mechanism of collagen materials repairing tissue damage is that when granulation tissue invades collagen materials, the inner layer of collagen can re-dissolve and absorb wound exudate, and then grow as cells. At t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08L1/04C08L1/02C08L89/00A61L15/32A61L15/28A61L27/40A61L27/24A61L27/20
Inventor 任伟业陈敬华陆金婷刘石林
Owner 无锡贝迪生物工程股份有限公司
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