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Space-induced efficient bifidobacterium longum, application thereof, and preparation method of capsule preparation thereof

A technology of bifidobacterium longum and space mutagenesis, applied in the field of microbiology, can solve the problems of instability of bifidobacterium mutant strains, easy inactivation of preservation and oral administration, difficulties in the production of live bacterial preparations, etc., and achieve the regulation of intestinal flora Effects of balance, enhancement of oxygen resistance, and improvement of acid production capacity

Active Publication Date: 2014-08-06
神舟太空集团(深圳)高科技有限公司
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Problems solved by technology

Although "replenishment of live bacteria in vitro" avoids the unsafe problems brought about by the method of "proliferation of live bacteria in vivo", bifidobacteria are a strict anaerobic bacteria, and the production of live bacteria preparations is difficult, and due to the impact of live bacteria on Sensitive to acids, bases, and heat, making preservation and oral inactivation prone
At the same time, the mutant strains of bifidobacterium induced by conventional mutagenesis are unstable and the yield is not high, which causes greater difficulties in the production of live bacterial preparations

Method used

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  • Space-induced efficient bifidobacterium longum, application thereof, and preparation method of capsule preparation thereof
  • Space-induced efficient bifidobacterium longum, application thereof, and preparation method of capsule preparation thereof
  • Space-induced efficient bifidobacterium longum, application thereof, and preparation method of capsule preparation thereof

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Embodiment Construction

[0072] The present invention will be described in detail below in combination with specific embodiments.

[0073] Bifidobacterium longum described in the present invention ( Bifidobacterium longum ) S7-T6, which was deposited on May 19, 2011 in the General Microbiology Center of China Committee for the Collection of Microbial Cultures, the address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, and the deposit number is CGMCC No. 4887.

[0074] The experimental methods in the following content, unless otherwise specified, are conventional methods; the experimental materials used in the following examples, unless otherwise specified, are conventional biochemical reagents.

[0075] 1. Mutagenesis of Bifidobacterium longum:

[0076] Bifidobacterium longum with the preservation number CGMCC 1.2186 was used as the starting strain, and the number was S7-D6, which was divided into 2 parts, 1 part was stored at ...

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Abstract

The invention relates to space mutagenesis of high-efficiency bifidobacterium longum, its application and a preparation method of capsule preparation. Bifidobacterium is a strict anaerobic bacteria. It is difficult to produce live bacteria preparations, and because the live bacteria are sensitive to acid, alkali and heat, it is easy to cause inactivation during storage and oral administration. The invention provides a strain of Bifidobacterium longum S7-T6, which can be applied to the preparation of medicines and health care products for regulating intestinal flora balance and treating diarrhea. The Bifidobacterium longum of the present invention has enhanced oxygen resistance and salt resistance, and can be stably inherited to 30 generations without degeneration; it can grow under the culture conditions with a content of 6% NaCl; the methyl red test and the VP test are positive, indicating that Its acid production ability is improved. It has been clinically verified that its live bacteria preparation can promote digestion, effectively regulate the balance of intestinal flora, and can be used to prepare health care products or medicines.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a strain of high-efficiency Bifidobacterium longum induced by space mutation, its application and a preparation method of a capsule preparation. Background technique [0002] Bifidobacterium longum, Latin scientific name Bifidobacterium longum , belonging to the genus Bifidobacterium, Bifidobacterium Orla-Jensen is an anaerobic Gram-positive bacillus isolated from the feces of breast-fed infants by the French scholar Tissier in 1899. The ends are often forked, so named Bifidobacteria. With the rise of microecology and the progress of the medical revolution in the past two decades, the importance of bifidobacteria research has been increasingly recognized. [0003] Bifidobacterium is a physiological bacterium in the human gastrointestinal tract. It is a beneficial bacterium. It is inseparable from the health of the human body. The most common distribution is in breast-fed infa...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/74A61K9/48A61P1/00A61P1/12A23L1/29A23P1/04C12R1/01A23L33/00A23P10/30A61K35/745
Inventor 赵恒
Owner 神舟太空集团(深圳)高科技有限公司
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