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A kind of hemostatic starch and preparation method thereof

A starch and modified starch technology, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of unstable preparations and low water absorption of modified starches, and achieve the effects of stable preparations, improved water absorption performance, and convenient preparation

Active Publication Date: 2016-03-30
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] An object of the present invention is to provide a new hemostatic starch, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption and unstable preparations of modified starch in the prior art.

Method used

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  • A kind of hemostatic starch and preparation method thereof
  • A kind of hemostatic starch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The hydroxypropyl distarch phosphate is etherified, cross-linked and esterified by chemical reagents such as propylene oxide and phosphoric acid to make a new modified starch, and then the modified starch slurry is put into the mixer, and the Under the condition of 85°C, the rotation speed of the stirrer was adjusted to 600r / min, and the duration was 150min. After cooling, it was filtered with suction, washed with alcohol, and dried to obtain hemostatic starch 1.

Embodiment 2

[0034] Put the hydroxypropyl distarch phosphate slurry into the agitator, adjust the rotation speed of the agitator to 600r / min at 85°C for 150min, filter with suction after cooling, wash with alcohol, dry, and then pass epoxy Chemical reagents such as propane and phosphoric acid undergo etherification, cross-linking, and esterification to make new modified starch, wash with alcohol, and dry to obtain hemostatic starch 2.

Embodiment 3

[0036] The hydroxyethyl starch is subjected to etherification, crosslinking and esterification with chemical reagents such as propylene oxide and phosphoric acid to make a new modified starch, and then the modified starch slurry is put into a stirrer and heated at 85 ° C. Adjust the rotation speed of the stirrer to 600r / min, and the duration is 150min. After cooling, filter with suction, wash with alcohol, and dry to obtain hemostatic starch 3.

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Abstract

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to a heat stirring treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for wound surface having blood.

Description

technical field [0001] The invention relates to a hemostatic starch and a preparation method thereof, in particular to a biocompatible hemostatic starch which can be directly used on bloody wounds and a preparation method thereof. Background technique [0002] Bleeding is the most likely phenomenon in accidents and medical treatment. A large amount of bleeding will endanger human life. Therefore, it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many kinds of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin starch, collagen starch and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; chitosan / chitin, starch polysaccharides and other natural biopolysaccharide hemostatic materials, etc. [0004] The content of the present invention relates to the hemostatic material of starc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/00C08B31/16A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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