Method for preparing hydrazone compound

Abstract

The invention discloses a method for preparing a hydrazone compound. The method is characterized in that an aldehyde compound is used to continuously chemically react with p-chlorophenylhydrazine hydrochloride under the protection of N2, and the reaction formula is shown as follows: p-ClC6H4N2H3-HCl+RCOCHO->p-ClC6H4NHNCH-COR+HCl+H2O, wherein R is any one of hydrogen, alkyl or hydroxyl. The method for preparing the hydrazone compound has the beneficial effects that the prepared hydrazone compound excludes polychlorinated biphenyl, the aldehyde compound is adopted and reacts with p-chlorophenylhydrazine hydrochloride, the reaction condition is controlled, and the process is optimized, therefore, the p-chlorophenylhydrazine hydrochloride can be reacted completely, polychlorinated biphenyl cannot be produced by the p-chlorophenylhydrazine hydrochloride, and production of dihydrazone impurities in the reaction can be avoided. The excessive aldehyde compound can be recycled, so that economy and environmental protection are realized.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, and in particular relates to a method for preparing hydrazone compounds. Background technique [0002] Polychlorinated biphenyls, alias chlorinated biphenyls, English name: Polychorinated biphenyls, referred to as PCBs. In my country, PCB is traditionally divided into trichlorobiphenyl (PCB3), tetrachlorobiphenyl (PCB4), pentachlorobiphenyl (PCB5), hexachlorobiphenyl (PCB3) Benzene (PCB6) and so on. PCBs are strong carcinogens that tend to accumulate in adipose tissue, causing diseases of the brain, skin and internal organs, and affecting nerves, reproduction and immunity. [0003] P-Chlorophenylhydrazine hydrochloride is often used as an intermediate in organic synthesis. PCBs will inevitably be produced during the drying and storage of p-chlorophenylhydrazine hydrochloride, although sometimes the content of PCBs is very low. Only 100ppm, but because polychlorinated biphenyls are stro...

AI Technical Summary

Problems solved by technology

[0003] P-Chlorophenylhydrazine hydrochloride is often used as an intermediate in organic synthesis. PCBs will inevitably be produced during the drying and storage of p-chlorophenylhydrazine hydrochloride, although sometimes the content of PCBs is very low. Only 100ppm, but because polychlorinated biphenyls are strong carcinogens, there is zero tolerance in the pharmaceutical, pesticide and food industries, so even a small amount is not allowed, so the unreacted p-chlorophenylhydrazine hydrochloride It is very necessary to remove

[0004] Hydrazone compounds are organic chemical intermediates that can form a series of nitrogen-containing heterocyclic compounds; they are important intermediates for medicine and pesticides. At present, there is no method for effectively preparing hydrazone compounds in China.