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Tongmai oral liquid raw material extract

A technology of raw material medicine and oral liquid, applied in the field of raw material medicine extract of Tongmai oral liquid, can solve problems such as neglect

Active Publication Date: 2015-04-15
SICHUAN GOODDOCTOR PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the inventor draws a preliminary conclusion from the prior art: the current preparation process of Tongmai Oral Liquid has certain defects. It only emphasizes the water-soluble components of the three medicinal materials, while ignoring tanshinone ⅡA, ligustilide, etc. Fat-soluble active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 crude drug extract of the present invention

[0043] Take 10g of Salvia miltiorrhiza, Pueraria lobata and Chuanxiong each (1:1:1), mix well, add 300mL of 95% v / v ethanol, heat to reflux for 1h, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 300 mL of 50% v / v ethanol to the dregs, heat and reflux for 1 hour, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 300 mL of water to the dregs, decoct for 2 hours, filter the decoction, evaporate to dryness, and combine the three extracts to obtain the crude drug extract of the present invention.

Embodiment 2

[0044] The preparation of embodiment 2 crude drug extracts of the present invention

[0045] Take 10g of Salvia miltiorrhiza, Pueraria lobata and Chuanxiong each (1:1:1), mix well, add 400mL of 70% v / v ethanol, heat to reflux for 1h, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 300 mL of 40% v / v ethanol to the dregs, heat and reflux for 1 hour, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 300 mL of water to the dregs, decoct for 2 hours, filter the decoction, evaporate to dryness, and combine the three extracts to obtain the crude drug extract of the present invention.

Embodiment 3

[0046] The preparation of embodiment 3 crude drug extracts of the present invention

[0047] Take 10g of Salvia miltiorrhiza, Pueraria lobata and Chuanxiong each (1:1:1), mix well, add 200mL of 85% v / v ethanol, heat to reflux for 1h, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 200 mL of 60% v / v ethanol to the dregs, heat and reflux for 1 hour, filter the extract, recover ethanol from the filtrate and concentrate to an appropriate amount. Add 200 mL of water to the dregs, decoct for 2 hours, filter the decoction, evaporate to dryness, and combine the three extracts to obtain the crude drug extract of the present invention.

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Abstract

The invention provides a Tongmai oral liquid raw material extract, which is characterized in that the ratio of Tongmai oral liquid raw materials is as follows: salvia miltiorrhiza: radix puerariae: ligusticum wallichii=1: 1: 1, and in the raw material extract, the weight ratio of the active ingredients is as follows: tanshinol: puerarin: ferulic acid: tanshinone IIA=(0.9-1.3): (1.0-1.3): (1.0-1.2): 1.0. According to the invention, alcohol and water are taken as solvents to extract the Tongmai oral liquid raw materials together; although the extraction efficiency for the active ingredients is not as good as extraction by using 60% alcohol, the raw material extract prepared by the method is obviously superior to the previous preparation process and the 60% alcohol extract with the highest active ingredient content in pharmacological activity; an unexpected technical effect is achieved; and the Tongmai oral liquid raw material extract is advantageous for the patients suffering cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to an extract of raw materials of Tongmai Oral Liquid and its preparation method and application. Background technique [0002] Tongmai Oral Liquid is composed of Danshen, Chuanxiong, and Pueraria lobata. The twentieth volume of the Ministry of Pharmaceutical Standards for Traditional Chinese Medicine Prescriptions. Tongmai Oral Liquid has classic prescriptions, refined medicinal taste, sufficient dosage, and definite curative effect. However, many reasons lead to its unsatisfactory market share, which hinders the pace of growing into a large variety of Chinese patent medicines. [0003] Tongmai Fang has the effect of promoting blood circulation and unblocking the veins, and it is mainly used clinically to treat ischemic cardiovascular and cerebrovascular diseases, arteriosclerosis, coronary heart disease, etc. According to literature reports, the active ingredients of Tongmai Oral Liquid are mainly water-soluble ingredients con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/08A61P9/10A61P25/00A61K31/58A61K31/352A61K31/192
Inventor 王达宾杨凤梅熊永爱邹俊波苏柘僮姜小东郭华
Owner SICHUAN GOODDOCTOR PHARMA GRP
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