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Chloro benzophenone compound and preparation method and application thereof

A technology of chlorinated benzophenones and compounds, which is applied in the field of chlorinated benzophenones and their preparation and application, and can solve the problems of poor selectivity and marine natural selective antibacterial agents that have not yet been seen.

Inactive Publication Date: 2013-07-24
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial agents currently used are mainly broad-spectrum antibacterial preparations with poor selectivity
In recent years, no marine natural selective antibacterial agent with important antibacterial value has been obtained from marine microorganisms.

Method used

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  • Chloro benzophenone compound and preparation method and application thereof
  • Chloro benzophenone compound and preparation method and application thereof
  • Chloro benzophenone compound and preparation method and application thereof

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Embodiment Construction

[0009] Preparation of Compounds of the Invention

[0010] (1) Culture of soft coral symbiotic fungi

[0011] The medium used for the culture of the soft coral symbiotic fungus Pestalotiopsis sp. (HM486429) contains 1.0% glucose (percentage by weight, the same below), 0.2% yeast extract, 0.2% peptone, 1.0% agar, and 3.0% sodium chloride , and the rest is water, which is made into a test tube slant when used, and the fungal strains are cultivated at 30°C for 5 days.

[0012] The strain culture medium contains glucose 0.1%-5.0% (weight percentage, the same below), yeast extract 0.01%-1%, peptone 0.01%-1%, agar 0.1%-3.0%, sodium chloride 0.05%- 5%, the rest is water.

[0013] (2) Fermentation of soft coral symbiotic fungi

[0014] The fermented medium used for the fermentation culture of soft coral symbiotic fungus Pestalotiopsis sp. (HM486429) contains glucose 1.0% (percentage by weight, the same below), yeast extract 0.2%, peptone 0.2%, sodium chloride 3.0%, and the rest is w...

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Abstract

The invention discloses a chloro benzophenone compound which is prepared by the following steps: firstly carrying out strain culture of Pestalotiopsis sp.(HM486429) in a strain culture medium; secondly, carrying out fermentation culture of the fungus in a fermentation culture medium, then extracting the obtained mycelium three times by using ethyl acetate and extracting the obtained mycelium three times by using a chloroform-methanol mixed solution (1:1), carrying out vacuum concentration so as to obtain a crude extract, carrying out chromatographic separation, and respectively concentrating the eluant so as to obtain white powder, which is pestalachloride D, wherein the structural identification is shown in the specification. The invention provides an antibacterial agent which has optical inhibitory activities for Vibrio parahaemolyticus, Vibrio anguillarum and Escherichia coli, can be used for developing optical antibacterial agents, and is wide in application prospect as the raw materials can be produced in a large scale through fungus fermentation and no resource limit exists.

Description

technical field [0001] The invention relates to a chlorinated benzophenone compound, a preparation method thereof and an application as an antibacterial agent. Background technique [0002] The unique living environment of marine microorganisms (high pressure, high salt, anoxic, dark, etc.) makes them an important source of new natural products with special activities, and also a valuable resource for innovative drug research and development. Pestalotiopsis sp. is a common fungus that widely exists in animals, plants and marine organisms. Since the discovery of the anticancer drug paclitaxel from the terrestrial fungus Pestalotiopsis microspora in 1996, various structural types of compounds have been obtained from the terrestrial fungus Pestalotiopsis microspora at home and abroad, including terpenes, alkaloids, phenols, lactones, etc. Many types, many of which have good biological activities, including antibacterial, anti-tumor, anti-oxidation, enzyme inhibitors, etc. Mos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/94C12P17/06A01N43/16A01P1/00C12R1/645
Inventor 王长云邵长伦邢倩
Owner OCEAN UNIV OF CHINA
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