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Raman strengthening active microsphere and preparation method and application thereof

A technology to enhance activity, microspheres, applied in the fields of microsphere preparation, Raman scattering, microcapsule preparation, etc., can solve the problem of low reproducibility and instability of Raman signals, cannot be differentiated and located one by one, "hot spots" Uneven distribution and other problems, to achieve good application prospects, reduce low reproducibility and instability, and achieve accurate and controllable coverage.

Inactive Publication Date: 2014-12-03
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many novel structures of nano-substrates with high Raman-enhancing activity have been developed, they cannot be distinguished and localized individually under conventional light microscopy, and the individuals cannot be manipulated, nor can they be moved from one site to another. specified site, so that many applications are limited
In addition, for nano-substrates, lasers were mostly focused on multiple microspheres in the past. Due to the uneven surface of each microsphere or the uneven distribution of "hot spots", it is easy to cause low reproducibility and unevenness of Raman signals. stability

Method used

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  • Raman strengthening active microsphere and preparation method and application thereof
  • Raman strengthening active microsphere and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: prepare the MF microsphere of different sizes

[0018] 1.1 Preparation of MF microspheres with MF size of 0.4 μm

[0019] Melamine 0.625g, formaldehyde 0.9g, used for alkali adjustment solution pH = 11, pre-polymerized at 100°C for 0.5 hours, then adjusted the pH to 4, reacted for 2 hours, left to stand, removed the upper emulsion, the obtained product was mixed with ethanol and The product was washed three times with water, and the product was separated. Finally, the product was vacuum-dried at 50°C to obtain MF microspheres with a particle size of about 0.4 μm.

[0020] 1.2 Preparation of MF microspheres with MF size of 1 μm

[0021] The procedure was the same as that described in Example 1.1, except that the reaction temperature was changed from 100 °C to 70 °C, and the amount of acid was 50 μL.

[0022] 1.3 Preparation of MF microspheres with MF size of 3 μm

[0023] The procedure was the same as that described in Example 1.1, except that the reacti...

Embodiment 2

[0026] Example 2: Preparation of MF / Ag-NPs composite microspheres and their application to detect 4-CBT at different concentrations.

[0027] The preparation of MF microspheres was the same as in Example 1.2, except that the amount of acid used was 7 μL. Add 10-200 mg of MF microspheres, 20-600 mg of silver nitrate, 10-300 mg of reducing agent and 10-200 mL of absolute ethanol into a centrifuge tube, and react in a shaker for 0.5-4 hours; after the reaction , centrifuged to obtain the product, and washed with absolute ethanol to obtain MF / Ag-NPs composite microspheres. Take 10mg MF / Ag-NPs microspheres and 5mL different concentrations (0~10 -9 Add the PCP solution of M) into a centrifuge tube and put it into a shaker for adsorption for 1h. The SERS signal of the sample was then detected using a Raman spectrometer.

Embodiment 3

[0028] Example 3: Preparation of MF / Ag-NPs composite microspheres and their application to detect different concentrations of 4-ABT.

[0029] The steps are the same as described in Example 2, except that the detection substance is changed from 4-CBT to 4-ABT, and the concentration is changed from 0 to 10 -9 M becomes 0~10 -10 .

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Abstract

The invention belongs to the technical field of function materials, and specifically relates to a Raman strengthening active microsphere and a preparation method and an application thereof. The Raman strengthening active microsphere provided by the invention has a core-shell structure, the core of the Raman strengthening active microsphere is a melamine resin microsphere, and the shell is uniform and compact silver nanometer granules. The preparation method comprises the steps of firstly preparing uniform melamine-oxymethylene microsphere through fasculation, then utilizing a reducing agent to restore silver nitrate through a normal position chemical reduction method, and uniformly and compactly depositing the generated silver nanometer granules onto the surface of the melamine resin microsphere, so as to prepare the MF / Ag-NPs composite microsphere. The raman strengthening active microsphere utilizes a single microsphere as a raman strengthening base material, and is used for detecting Raman. The single Raman strengthening active base material microsphere provided by the invention has the characteristics of high stability and high Raman strengthening property. The method provided by the invention has the advantages that the operation is simple, the process is controllable, and the prepared composite microsphere can be used for analyzing and detecting organic contaminants such as pesticide residue of a single microsphere in a Raman manner.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a Raman-enhanced active microsphere and its preparation method and application. Background technique [0002] Surface-enhanced Raman spectroscopy has high sensitivity, good selectivity, and rapid analysis; it does not destroy the structure of the sample during detection, and can provide non-destructive detection, and can provide single-molecule level detection (Kneipp, J.; Kneipp, H.; Kneipp, Kneipp, Kneipp, K . Chem. Soc. Rev. 2008, 37, 1052-1060. Doering, E.D; Nie, S.M. Anal. . 2003, 75, 6171-6176). Therefore, it has attracted extensive attention in chemical analysis, environmental detection, biological diagnosis and so on. Currently, SERS-enhanced substrates mainly include gold or silver rough surfaces, nanoparticles or aggregates deposited on the surface of dielectric microspheres. Dielectric microspheres / nanoparticles have become a research hots...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/14C08G12/32B22F9/24G01N21/65
Inventor 汪长春游力军
Owner FUDAN UNIV
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