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Vagina bacteriostatic virus-killing composition and application thereof

A technology for killing viruses and compositions, applied in the field of vaginal bacteriostatic compositions, can solve the problems that preservatives are only suitable for topical treatment, bring side effects, and are limited, and can restore normal physiological functions, protect the physiological environment, and reduce irritation. Effect

Active Publication Date: 2013-05-01
NANJING MESE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whereas antibiotics may be used for systemic or topical treatment, antiseptics may only be used for topical treatment
For bacterial vaginosis, antibiotic therapy is often limited due to systemic administration or causes side effects

Method used

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  • Vagina bacteriostatic virus-killing composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 0.10g polyhexamethylene biguanide hydrochloride, 0.10g disodium edetate, 2g glycerin, 0.6g hydroxyethyl cellulose, 0.15g sodium chloride, 0.2g lactic acid, add pure water or distilled water to 100ml, stir evenly, fill and test to obtain isotonic vaginal lotion with pH 4.0.

Embodiment 2

[0026] Take 0.05g polyhexamethylene biguanide hydrochloride, 1g disodium edetate, 5g glycerin, 1.0g hydroxyethyl cellulose, 0.05g sodium chloride, 0.1g lactic acid, add purified water to 100ml, Stir evenly, fill and test to obtain isotonic vaginal lotion with pH 4.2.

Embodiment 3

[0028] Take 1 g of polyhexamethylene biguanide hydrochloride, 0.05 g of disodium edetate, 10 g of glycerin, 0.1 g of hydroxyethyl cellulose, 1.5 g of sodium chloride, and 0.5 g of lactic acid, add distilled water to 100 ml, and stir After uniformity, it is filled and inspected to obtain an isotonic vaginal lotion of pH 4.4.

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PUM

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Abstract

The invention discloses a vagina bacteriostatic virus-killing composition and application thereof. The vagina bacteriostatic virus-killing composition is composed of the following materials in part by weight: 0.01 to 3 parts of poly-hexamethylene biguanide hydrochloride, 0.01 to 3 parts of disodium EDTA, 0.2 to 60 parts of glycerol, 0.06 to 1.8 parts of hydroxyethyl cellulose, 0.015 to 4.5 parts of sodium chloride, and 0.02 to 6 parts of lactic acid. The composition not only is bacteriostatic and virus-killing, but also cannot kill normally parasitic lactobacillus in a vagina, so as to protect the balance of the microecosystem of the vagina. The composition can be used for preparing medicines, medical instruments and disinfectant curing bacterial and viral infection, thereby providing convenience for the vagina to recover normal physiological functions.

Description

technical field [0001] The invention relates to a medical device, medicine or disinfectant directly used for vaginal douching, in particular to a vaginal antibacterial composition and application thereof. Background technique [0002] In clinical practice, treatment of genital infections is based on either antibiotic or antiseptic administration. Whereas antibiotics may be used for systemic or topical treatment, antiseptics may only be used for topical treatment. For bacterial vaginosis, antibiotic therapy is often limited or has side effects due to systemic administration. Peformin is a promising drug for the treatment of localized genital infections, especially bacterial vaginosis and vaginitis. [0003] Polyhexamethylenebiguanide hydrochloride (PHMB), also known as polyhexamethyleneguanidine hydrochloride, is a biguanide compound with a molecular formula of C8H17N5. The polyhexamethyleneguanidine hydrochloride raw material product is a colorless transparent liquid, the...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61P31/04A61P31/12A61P31/10A61P31/18A61P31/20A61P15/02A61P33/02A01N47/44A01P1/00A01P3/00
Inventor 季刚张磊王殿广范丽芳赵萍陈萍
Owner NANJING MESE PHARMA
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