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Pharmaceutical composition containing lappaconitine and oxycodone

A technology of homogenin and homogenin hydrobromide, which is applied in the field of medicine

Active Publication Date: 2015-02-11
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After long-term injection of homo-urinine to monkeys, the monkeys do not appear any withdrawal syndrome after stopping the drug. After long-term injection of LH to mice, and then given acrylmorphine to induce addiction, there is no jumping reaction, but LH has no effect on morphine-dependent rats. or withdrawal symptoms after drug withdrawal in monkeys without substitution

Method used

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  • Pharmaceutical composition containing lappaconitine and oxycodone
  • Pharmaceutical composition containing lappaconitine and oxycodone
  • Pharmaceutical composition containing lappaconitine and oxycodone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1——tablet containing homogenate and oxycodone

[0063] prescription:

[0064] Tablets:

[0065]

[0066] Film Coating Prescription:

[0067]

[0068]

[0069] Preparation method: pass the prescribed amount of urine, oxycodone, microcrystalline cellulose and 200g starch through an 80-mesh sieve and mix evenly, use 10% PVP K-30 aqueous solution as a binder to make granules and dry, dry Mix the granules with the rest of dried starch and micropowder silica gel, and press plain tablets with different weights, each tablet contains 10mg / 10mg, 5mg / 5mg, or 2.5mg / 2.5mg of oxycodone . Then coat the plain tablet again until the weight of the tablet increases by 3-4%.

Embodiment 2

[0070] Embodiment 2——tablet containing homogenate and oxycodone

[0071] prescription:

[0072]

[0073] Preparation method: pass the prescribed amount of urine, oxycodone, microcrystalline cellulose and 200g starch through an 80-mesh sieve and mix evenly, use 10% PVP K-30 aqueous solution as a binder to make granules and dry, dry The granules are mixed with the remaining dried starch and micropowder silica gel, and tablets of different tablet weights are pressed. Each tablet contains 5 mg / 10 mg, 2.5 mg / 5 mg, or 1.25 mg / 2.5 mg / oxycodone respectively mg.

Embodiment 3

[0074] Embodiment 3——tablet containing homogenate and oxycodone

[0075] prescription:

[0076]

[0077]

[0078] Preparation method: refer to the method of Example 2 to prepare granules and compress into tablets.

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Abstract

The invention relates to a pharmaceutical composition containing lappaconitine and oxycodone for treating pain. The pharmaceutical composition contains a treatment effective quantity of lappaconitine or a pharmaceutically acceptable salt thereof or a solvate thereof, a treatment effective quantity of oxycodone or a pharmaceutically acceptable salt thereof and an optional pharmaceutically acceptable carrier. The invention further relates to a use of the composition containing the treatment effective quantity of lappaconitine or the pharmaceutically acceptable salt thereof or the solvate thereof and the treatment effective quantity of oxycodone or the pharmaceutically acceptable salt thereof in the preparation of medicines for relieving pain. The pharmaceutical composition and the use, disclosed by the invention, have the beneficial effects as described in the specification.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a pharmaceutical composition for preventing or treating pain, in particular to a pharmaceutical composition containing homogenate and oxycodone. Background technique [0002] Pain is an unpleasant sensory and emotional experience that occurs when the body is damaged. It is a clinical manifestation of a group of complex pathological and physiological changes. Pain can be local or a reflection of systemic diseases. Diseases in which "pain" is the main symptom are collectively referred to as "pain". In addition, some strong analgesics are often used clinically, for example, for pain caused by postoperative, trauma, cancer, etc. However, many analgesics are prone to dependence / addiction, and once mental dependence occurs, it will bring new and bigger problems to clinical medication. [0003] Lappaconitine (LA), also known as aconitine and labaconitine, as a long-acting analgesic, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485
Inventor 高永良李莉娥孙建宁刘泽源
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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