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Magnetic resonance scanning method of gastrocnemius muscles of machins

A technique for magnetic resonance scanning, gastrocnemius, used in medical science, sensors, diagnostic recording/measurement, etc.

Inactive Publication Date: 2013-04-03
GUANGXI WEIMEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The research on gastrocnemius muscle of cynomolgus monkeys provides a good basis for human gastrocnemius diseases, but the research on gastrocnemius muscle of cynomolgus monkeys is almost blank in the prior art. The study provides a stable and reliable detection method, which plays an important role in the development of gastrocnemius muscle research in cynomolgus monkeys

Method used

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  • Magnetic resonance scanning method of gastrocnemius muscles of machins
  • Magnetic resonance scanning method of gastrocnemius muscles of machins

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Embodiment 1

[0012] Cynomolgus monkey, male, about 4 years old, weighing about 4.8kg, provided by Guangxi Weimei Biotechnology Co., Ltd., ordinary grade, license number: SCXK Gui 2007-2, entered the animal room for 2 weeks of quarantine. The animal laboratory is an ordinary environment, with a temperature of 20-26°C, a relative humidity of 40-70%, mechanical air supply and exhaust, an illumination of 150-300Lux, and a lighting time of 12h / 12h. The cages were sterilized before they were put into use, and they were kept in single cages. Feed was added once a day in the morning and afternoon, fruit was given once a day, and water was free to drink.

[0013] MRI scans are performed as follows:

[0014] Anesthesia: Anesthetize the cynomolgus monkey with 2% pentobarbital sodium (5mg / kg) intravenously and lie supine, use a sponge pad to flatten the lower limb under inspection and fix it with a sandbag, and use a body coil to place the lower limb under inspection on the detection side. The cente...

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Abstract

The invention provides a scanning method of the gastrocnemius muscles of machins. According to the scanning method, a PHILIPS Achieva 1.5T magnetic resonance machine is used for scanning, wherein the T1 scanning sequence is IR, the visual field is 40cm*40cm, and TR / TE is 561ms / 17ms; and a T2 weighted image scanning sequence is SE, TR / TE is 3900ms / 102ms, layer thickness / interval is 5mm / 0.5mm, and the matrix is 320*320. The magnetic resonance scanning method of the gastrocnemius muscles of the machins can provide a clear magnetic resonance image of the gastrocnemius muscles of the machins and has a larger meaning in terms of muscle volume measurement, disease research and the like.

Description

technical field [0001] The invention relates to a method for magnetic resonance scanning of the gastrocnemius muscle of cynomolgus monkeys. It should be noted that the invention does not belong to a method for diagnosing and treating diseases, but a method for presenting the gastrocnemius muscle structure or experimental markers of experimental animals. Background technique [0002] Cynomolgus monkeys, also known as long-tailed monkeys and Javan monkeys. The cynomolgus monkey has a long life cycle and its biological characteristics are very similar to humans. It is the best experimental animal for studying human diseases. The animal model of human diseases established with it is conducive to observing the occurrence and development of diseases and complications. Efficacy testing and safety evaluation provide reliable guarantees, and have gradually become a primate experimental animal that is widely used in scientific research and drug research. [0003] The gastrocnemius mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
Inventor 杨继红刘雪萍梁福东杨波刘炜韦祝梅
Owner GUANGXI WEIMEI BIOTECH
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