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Novel efficient synbiotics intestines-targeting microspheric capsule and preparation method thereof

A synbiotic and targeting technology, applied in the field of novel high-efficiency synbiotic intestinal-targeting microsphere capsules and preparation thereof, can solve the problems of being easily affected by external environmental factors, low survival rate of probiotics, and high production costs, and achieves a beneficial effect. Effects of human health and environmental protection, improved feed utilization, and low production costs

Active Publication Date: 2013-04-03
ANHUI ZHENGDAYUAN FEED GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most micro-ecological live bacteria agents have the following problems: the content of live bacteria in probiotic preparations is low, and the production cost is high; The problem of low survival rate of probiotics entering the intestinal tract

Method used

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  • Novel efficient synbiotics intestines-targeting microspheric capsule and preparation method thereof
  • Novel efficient synbiotics intestines-targeting microspheric capsule and preparation method thereof
  • Novel efficient synbiotics intestines-targeting microspheric capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Synbiotics Intestinal Targeting Microsphere Capsules

[0030] A new type of high-efficiency synbiotic gut-targeting microsphere capsule, its components are: 40% probiotics and 60% prebiotics; the probiotics are composed of 50% Clostridium butyricum and 50% Lactobacillus bacilli; the prebiotics are a mixture of 70% cerevisiae polysaccharide and 30% sulfated cerevisiae polysaccharide.

[0031] The preparation method of novel high-efficiency synbiotic intestinal targeting microsphere capsule comprises the following steps:

[0032] (1) Preparation of probiotics

[0033] ① Preparation of Lactobacillus

[0034] Lactobacillus culture medium is: yeast extract 10g, peptone 10g, glucose 6g, MgSO 4 ·7H 2 O 1g, MnSO 4 0.05g, K 2 HPO 4 2g, 1L of distilled water, PH=7.2, sterilization condition is 121℃, 30min;

[0035] Step 1: Inoculate the strains on the slant into a test tube containing Lactobacillus culture medium, and inoculate at a constant te...

Embodiment 2

[0051] Example 2: Synbiotics intestinal targeting microsphere capsule storage period test

[0052] Put the synbiotic intestinal-targeted microsphere capsules prepared in Example 1 into a medicine bottle, seal the seal with wax, and keep the temperature constant at 4°C refrigerator, 25°C room temperature, 37°C accelerated test and 75% relative humidity (RH75%) Storage, the total number of bacteria in the capsules at different times and the contents of the three kinds of bacteria in the capsules after storage for one year were measured respectively. The results are shown in Tables 1 and 2.

[0053] Table 1 Changes in the number of viable bacteria in the gut-targeted microsphere capsules of synbiotics at different temperatures

[0054]

[0055] Table 2 Contents of two kinds of bacteria in synbiotics gut-targeted microsphere capsules stored at different temperatures for 1 year

[0056]

[0057] As can be seen from Table 1 and Table 2, the survival rates of the two kinds of ...

Embodiment 3

[0058] Embodiment 3: Experiment of simulated artificial gastric juice and intestinal juice

[0059] Take 4 capsules, put 1 capsule in each 250mL Erlenmeyer flask containing 100mL simulated artificial gastric juice, shake and dissolve in a constant temperature water bath shaker at 37°C at 150r / min, and take samples every 0.5h within 4h , neutralize the acidity, take the rapidly mixed artificial gastric juice to detect its survival rate and the number of live bacteria, take the mean value to analyze the dissolution situation in the artificial gastric juice, the results are shown in Table 3.

[0060] Table 3 Dissolution of synbiotics in artificial gastric juice

[0061]

[0062] It can be seen from Table 3 that in the artificial gastric juice, the survival rate of viable bacteria reached 78.2% within 2 hours, and the total viable bacteria was 1.76×10 10 cfu·g -1 . From 1.5h onwards, the survival rate decreased slowly, because the combination of prebiotics and probiotics at ...

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Abstract

The invention discloses a novel efficient synbiotics intestines-targeting microspheric capsule and a preparation method of the novel efficient synbiotics intestines-targeting microspheric capsule. The novel efficient synbiotics intestines-targeting microspheric capsule comprises 30-40% of probiotics and 60-70% of prebiotics, wherein the probiotics is a mixture composed of 40 to 50% of clostridia butyricum and 50 to 60% of lactobacillus sporogenes; and the prebiotics is the mixture composed of 60 to 70% of cerevisiae zymosan and 30 to 40% of sulphated cerevisiae zymosan. The novel micro-capsule synbiotics additive for the feed, prepared by the method disclosed by the invention, plays the effects of both the probiotics and the prebiotics, has remarkable effects of improving the utilization rate of the feed, promoting the growth of animal and improving the resistance and immunity of the human body; and the novel efficient synbiotics intestines-targeting microspheric capsule is sable in quality, safe, and free from toxic and side effect, brings no residues and pollution, and is beneficial for the human health and environmental protection.

Description

technical field [0001] The invention relates to a feed additive, in particular to a novel high-efficiency synbiotic intestinal targeting microsphere capsule and a preparation method thereof. Background technique [0002] Antibiotics have played a huge role in animal production for a long time. It can effectively treat and prevent animal diseases, but the continuous use of antibiotics will cause many problems such as bacterial resistance and drug residues in animal products. Therefore, seeking and developing green, Pollution-free and residue-free feed additives to replace antibiotic feed additives have become a hot research topic in the current feed industry. [0003] Synbiotics, also known as synbiotics, were first proposed by Gibson (1995). It refers to the combination of probiotics (Probiotics) and prebiotics (Prebiotics) biological preparations, which is characterized by the simultaneous use of probiotics and prebiotics. The use effect of synbiotics is equivalent to or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23K1/00
Inventor 彭庆付孟玲琳顾玉芹王清伟
Owner ANHUI ZHENGDAYUAN FEED GRP CO LTD
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